Low-dose aspirin does not affect the renal function of microalbuminuric type 2 Diabetic patients

Autores

  • Eduardo Guimaraes Camargo UFRGS
  • Leticia Schwerz Weinert UFRGS
  • Ariana Aguiar Soares UFRGS
  • Mariana Nunes Ferreira UFRGS
  • Gustavo Neves Araujo UFRGS
  • Sandra Pinho Silveiro UFRGS

Palavras-chave:

aspirin, diabetic nephropathy, GFR, glomerular filtration rate, microalbuminuria,

Resumo

BACKGROUND: Low-grade inflammation has been implicated in the pathogenesis of diabetic nephropathy, and anti-inflammatory drugs could be potentially useful as a therapeutic tool. The aim of this study was to analyze the effect of low-dose aspirin (300 mg/d) on urinary albumin excretion (UAE) and glomerular filtration rate (GFR) levels of microalbuminuric type 2 DM patients.

METHODS: In this randomized, double-blind, crossover, placebo-controlled study, 18 microalbuminuric (UAE=30-300 mg/24 h) type 2 DM patients received aspirin (300 mg/d) or identical placebo for 8 weeks, with a 6-week washout period. The patients were aged 56±9 years, had a diabetes duration of 16±7.5 years; 11 (61%) were female, and they were all using enalapril 10 mg bid. GFR was measured by 51Cr-EDTA single-injection method and UAE by immunoturbidimetry. The sample-size calculation showed that 17 patients were needed to detect a 30% change in UAE (α= 0.05 and β= 0.20).

RESULTS: After 8 weeks of treatment, there were no significant differences between placebo and aspirin, respectively, regarding UAE [57.7 (8.9-420.0) vs. 63 (8.2-272.0) mg/24 h; P=0.45] and GFR (108±34 vs. 111±47 ml/min/1.73 m2; P=0.90). C-reactive protein levels [2.72 (0.34-10.3) vs. 2.03 (0.25-10.3) μg/l; P=0.21] were comparable after placebo and aspirin, respectively. There were no period (P=0.41) or carry-over effects (P=0.49).

CONCLUSION: Low-dose aspirin did not affect GFR and UAE levels of microalbuminuric type 2 DM. It seems that the putative low-grade inflammation of diabetic nephropathy does not respond to these low doses of the drug.

Downloads

Não há dados estatísticos.

Biografia do Autor

Eduardo Guimaraes Camargo, UFRGS

PPG Ciências Médicas: Endocrinologia

Leticia Schwerz Weinert, UFRGS

PPG Ciências Médicas: Endocrinologia

Ariana Aguiar Soares, UFRGS

PPG Ciências Médicas: Endocrinologia

Sandra Pinho Silveiro, UFRGS

Departamento de Medicina Interna, UFRGS

Serviço de Endocrinologia, HCPA

Downloads

Publicado

2012-01-27

Como Citar

1.
Camargo EG, Weinert LS, Soares AA, Ferreira MN, Araujo GN, Silveiro SP. Low-dose aspirin does not affect the renal function of microalbuminuric type 2 Diabetic patients. Clin Biomed Res [Internet]. 27º de janeiro de 2012 [citado 28º de novembro de 2022];31(4). Disponível em: https://seer.ufrgs.br/index.php/hcpa/article/view/24313

Edição

Seção

Artigos Originais

Artigos mais lidos pelo mesmo(s) autor(es)

1 2 3 4 > >>