Role of advanced glycation end products related to the onset of diabetic kidney disease complications

Autores

  • Maria Luiza Almeida de Paula Medical School, Universidade Federal Fluminense (UFF), Niteroi, RJ, Brazil
  • Ana Marina Rodrigues Villela Medical School, Universidade Federal Fluminense (UFF), Niteroi, RJ, Brazil
  • Mauricio Massucati Negri Medical School, Universidade Federal Fluminense (UFF), Niteroi, RJ, Brazil
  • Salim Kanaan Department of Pathology, Universidade Federal Fluminense (UFF), Niteroi, RJ, Brazil
  • Luciene de Carvalho Cardoso Weide Department of Pathology, Universidade Federal Fluminense (UFF), Niteroi, RJ, Brazil

Palavras-chave:

Type 2 diabetes mellitus, advanced glycation end products, endothelial dysfunction, hyperglycemia, oxidative stress, vascular complication, diabetic nephropathy

Resumo

Advanced glycation end products are known to play an important role in the diabetes complications, such as diabetic nephropathy. Most known pathways of diabetic complications involve oxidative stress, that have pivotal role in cell dysfunction onset and progression of angiopathies. This review will explore how AGEs cause endothelial dysfunction in diabetes and what current biochemical mechanisms have been proposed as an explanation for the development of diabetic nephropathy.

Keywords: Type 2 diabetes mellitus; advanced glycation end products; endothelial dysfunction; hyperglycemia; oxidative stress; vascular complication; diabetic nephropathy 

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Publicado

2017-12-15

Como Citar

1.
de Paula MLA, Villela AMR, Negri MM, Kanaan S, Weide L de CC. Role of advanced glycation end products related to the onset of diabetic kidney disease complications. Clin Biomed Res [Internet]. 15º de dezembro de 2017 [citado 7º de outubro de 2022];37(4). Disponível em: https://seer.ufrgs.br/index.php/hcpa/article/view/74457

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