Resistance of Helicobacter pylori to antibiotics used in different therapeutic schemes: an integrative review

Helicobacter pylori resistance to antibiotics used in different therapeutic regimens

Authors

  • Silvana Barbosa Santiago Instituto de Patologia Tropical e Saúde Pública, Núcleo de Estudo da Helicobacter pylori, Departamento de Biociências e Biotecnologia, Universidade Federal de Goiás. Goiânia, GO, Brasil. https://orcid.org/0000-0001-7948-8421
  • Jéssica Alves Rodrigues Instituto de Patologia Tropical e Saúde Pública, Núcleo de Estudo da Helicobacter pylori, Departamento de Biociências e Biotecnologia, Universidade Federal de Goiás. Goiânia, GO, Brasil.
  • Felipe Augusto de Sousa Moraes Instituto de Patologia Tropical e Saúde Pública, Núcleo de Estudo da Helicobacter pylori, Departamento de Biociências e Biotecnologia, Universidade Federal de Goiás. Goiânia, GO, Brasil.
  • Gabriel Ribeiro Maximo Instituto de Patologia Tropical e Saúde Pública, Núcleo de Estudo da Helicobacter pylori, Departamento de Biociências e Biotecnologia, Universidade Federal de Goiás. Goiânia, GO, Brasil.
  • Giovana Alice Sampaio Soares Instituto de Patologia Tropical e Saúde Pública, Núcleo de Estudo da Helicobacter pylori, Departamento de Biociências e Biotecnologia, Universidade Federal de Goiás. Goiânia, GO, Brasil.
  • Mônica Santiago Barbosa Instituto de Patologia Tropical e Saúde Pública, Núcleo de Estudo da Helicobacter pylori, Departamento de Biociências e Biotecnologia, Universidade Federal de Goiás. Goiânia, GO, Brasil.

DOI:

https://doi.org/10.22491/2357-9730.125639

Keywords:

Helicobacter pylori; Antibiotics; Treatment.

Abstract

Helicobacter pylori is a gram-negative bacterium that colonizes the gastric mucosa of more than half of the world's population. Eradication is performed with first-line triple therapy to reduce the onset of infection-related gastric disease. H. pylori was considered by the World Health Organization as one of the main bacteria that need new strategies for drug development. The aim of this study was to describe the pattern of resistance of H. pylori to antibiotics used in different therapeutic regimens. This is an integrative review, whose articles were surveyed in the PubMed, LILACS, Science Direct and SciElo databases. The inclusion criteria were studies published in Portuguese and English, indexed in the last ten years, with free access in full and that addressed the theme. The results showed mean resistance rates to metronidazole of 47.6%, levofloxacin of 24.7% and clarithromycin of 24.6%. For tetracycline and amoxicillin the means were 1.5% and 0.9% respectively. These results demonstrate varying patterns of resistance and reinforce the need to develop new drugs. It is concluded that the abusive use of antibiotics has led to increased resistance of H. pylori to the antibiotics used in its eradication.

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Author Biographies

Felipe Augusto de Sousa Moraes, Instituto de Patologia Tropical e Saúde Pública, Núcleo de Estudo da Helicobacter pylori, Departamento de Biociências e Biotecnologia, Universidade Federal de Goiás. Goiânia, GO, Brasil.

Bachelor in Biomedicine, graduated from the Federal University of Goiás (UFG). He served as a monitor of General Microbiology with an emphasis on Bacteriology at the Institute of Tropical Pathology and Public Health (IPTSP) at UFG. He served as a student of Voluntary Scientific Initiation in Bacteriology at IPTSP. Author of two e-books, namely, Practical Classes in Human Bacteriology and Practical Classes in Basic Bacteriology, published by the Integrated Center for Network Learning at UFG (CIAR-UFG). He is currently part of the Helicobacter pylori Study Center (NEHP).

Gabriel Ribeiro Maximo, Instituto de Patologia Tropical e Saúde Pública, Núcleo de Estudo da Helicobacter pylori, Departamento de Biociências e Biotecnologia, Universidade Federal de Goiás. Goiânia, GO, Brasil.

Graduating in Biotechnology at the Federal University of Goiás. Participates in the Helicobacter pylori Study Center - NEHP as a student of the Institutional Scientific Initiation Scholarship Program. Interested in Microbiology, Molecular Biology and Nanotechnology.

Giovana Alice Sampaio Soares, Instituto de Patologia Tropical e Saúde Pública, Núcleo de Estudo da Helicobacter pylori, Departamento de Biociências e Biotecnologia, Universidade Federal de Goiás. Goiânia, GO, Brasil.

Bachelor in Biomedicine from the Federal University of Goiás (UFG). She served as a General Microbiology monitor (IPTSP/UFG). She served on the Board of the Academic League of Neuropsychobiology Education (LAEN). She is currently part of the Helicobacter pylori Study Center (NEHP).

Mônica Santiago Barbosa, Instituto de Patologia Tropical e Saúde Pública, Núcleo de Estudo da Helicobacter pylori, Departamento de Biociências e Biotecnologia, Universidade Federal de Goiás. Goiânia, GO, Brasil.

Graduada em Biomedicina pela Universidade Federal de Goiás. Mestrado em Biologia pela Universidade Federal de Goiás. Doutorado em Ciências Biológicas pelo Instituto de Biologia da Universidade de Brasília (UnB), com ênfase em Biotecnologia de microrganismo. Durante seu doutoramento realizou pesquisa de antígenos visando diagnóstico e produção de vacinas recombinantes, com vários artigos publicados em revista de impacto internacional. Atualmente desenvolve projetos utilizando ferramentas da biotecnologia no estudo da bactéria patogênica humana Helicobacter pylori, com artigos publicados em revistas científicas e trabalhos apresentados em congressos nacionais e internacionais, atuando principalmente nos seguintes temas: Antígenos, Vacinas, Expressão Heteróloga de Proteínas. Foi Professora contratada da Universidade Estadual de Goiás (UEG) e Professora efetiva do Centro Universitário de Goiás (UNI-Anhanguera), Faculdade Araguaia e Faculdade Tamandaré. Também foi Professora-Substituta de Genética Molecular da Universidade Federal de Goiás (ICB-UFG)- Campus: Goiânia. Atualmente é professora Associada da Universidade Federal de Goiás - IPTSP.

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Published

2023-09-05

How to Cite

1.
Barbosa Santiago S, Alves Rodrigues J, de Sousa Moraes FA, Ribeiro Maximo G, Sampaio Soares GA, Barbosa MS. Resistance of Helicobacter pylori to antibiotics used in different therapeutic schemes: an integrative review: Helicobacter pylori resistance to antibiotics used in different therapeutic regimens. Clin Biomed Res [Internet]. 2023 Sep. 5 [cited 2025 Aug. 29];43(2). Available from: https://seer.ufrgs.br/index.php/hcpa/article/view/125639

Issue

Vol. 43 No. 2 (2023): Clinical and Biomedical Research

Section

Review Articles

Categories

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Copyright (c) 2023 Jéssica Alves Rodrigues, Felipe Augusto de Sousa Moraes, Gabriel Ribeiro Maximo, Giovana Alice Sampaio Soares, Mônica Santiago Barbosa, Silvana Barbosa Santiago

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