Morphine influence on esophageal carcinogenesis induced by diethylnitrosamine in rats - preliminary results
DOI:
https://doi.org/10.22491/2357-9730.125711Keywords:
Epidermoid esophageal carcinoma, esophageal carcinogenesis, nitrosamines, morphineAbstract
OBJECTIVE: In northern Iran, the high incidence of esophageal cancer was associated to opium. Diethylnitrosamine (DEN) is one of the nitrosamines that presents high risk for experimental cancer of the esophagus. Morphine, the largest alkaloid of opium, has been reported to increase the ethylation of esophageal DNA through DEN and to reduce first-passage hepatic metabolism, when administered in high doses to rats. Our objective was to study the effect of joint administration of morphine and DEN on esophageal carcinogenesis in rats.
MATERIAL AND METHODS: For 23 weeks, we studied the effect of joint administration of morphine and DEN on the esophageal carcinogenesis in rats.
RESULTS: The animal models that received only DEN presented a higher incidence of tumors than those that received DEN and morphine.
CONCLUSION: We concluded that morphine did not influence esophageal carcinogenesis induced by DEN in rats.
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