Intestinal microbiota changes after solid organ transplantation: a systematic review

Authors

  • Cristina Carra Forte Programa de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre, RS, Brasil.
  • Elis Forcellini Pedrollo Programa de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre, RS, Brasil.
  • Gabriela Corrêa Souza Departamento de Nutrição, Faculdade de Medicina, Universidade Federal do Rio Grande do Divisão de Nutrição, Hospital de Clínicas de Porto Alegre (HCPA). Porto Alegre, RS, Brasil.
  • Cristiane Bauermann Leitão Programa de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre, RS, Brasil. Divisão de Endocrinologia, Hospital de Clínicas de Porto Alegre (HCPA). Porto Alegre, RS, Brasil.

Keywords:

Transplantation, intestinal microbiota, outcomes

Abstract

 

Introduction: The intestinal microbiota may undergo changes after solid organ transplantation. The purpose of this systematic review was to characterize the intestinal microbiota of patients undergoing solid organ transplantation.

Methods: MEDLINE, EMBASE and Cochrane Library databases were searched from inception to July 21, 2017. Studies of patients undergoing solid organ transplantation that evaluated changes in intestinal microbiota composition and one of the following outcomes were included: post-transplant weight, new-onset diabetes after transplantation, delayed graft function, acute rejection, graft and patient survival, and post-transplant infections.

Results: Out of 765 studies found in this search, two studies (86 patients) fulfilled inclusion criteria. Both studies assessed kidney transplantation recipients, and a reduction in bacterial species diversity after transplantation was observed. Changes in intestinal microbiota were associated with acute rejection in both studies. One study reported diarrhea and urinary infections, while the other one reported urinary and respiratory infections. None of them reported other outcomes of interest.

Conclusion: Changes in intestinal microbiota were observed after kidney transplantation, and they were associated with higher incidence of acute rejection and infections in transplant recipients. However, data are still scarce and more studies are needed to evaluate if microbiota changes have an impact on post-transplant outcomes.

Keywords: Transplantation; intestinal microbiota; outcomes 

Downloads

Download data is not yet available.

Author Biographies

Cristina Carra Forte, Programa de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre, RS, Brasil.

Nutricionista, M.D. Programa de Pós-Graduação em Ciências Médicas: Endocrinologia

Elis Forcellini Pedrollo, Programa de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre, RS, Brasil.

Nutricionista, Ph.D. Student. Programa de Pós-Graduação em Ciências Médicas: Endocrinologia

Gabriela Corrêa Souza, Departamento de Nutrição, Faculdade de Medicina, Universidade Federal do Rio Grande do Divisão de Nutrição, Hospital de Clínicas de Porto Alegre (HCPA). Porto Alegre, RS, Brasil.

Ph.D. Departamento f Nutrition, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre; Division of Nutrition, Hospital de Clinicas de Porto Alegre

Cristiane Bauermann Leitão, Programa de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre, RS, Brasil. Divisão de Endocrinologia, Hospital de Clínicas de Porto Alegre (HCPA). Porto Alegre, RS, Brasil.

Ph.D. Programa de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul, Porto Alegre; Division of Endocrinology, Hospital de Clínicas de Porto Alegre

Downloads

Published

2018-04-11

How to Cite

1.
Carra Forte C, Forcellini Pedrollo E, Corrêa Souza G, Bauermann Leitão C. Intestinal microbiota changes after solid organ transplantation: a systematic review. Clin Biomed Res [Internet]. 2018 Apr. 11 [cited 2025 May 6];38(1). Available from: https://seer.ufrgs.br/index.php/hcpa/article/view/78354

Issue

Vol. 38 No. 1 (2018): Clinical and Biomedical Research

Section

Review Articles

License

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

Most read articles by the same author(s)