The role of intestinal microbiota in energetic metabolism: new perspectives in combating obesity

Authors

  • Juliana Pereira Perpétuo Instituto de Pesquisas, Ensino e Gestão em Saúde (IPGS)
  • Maria Inês de Albuquerque Wilasco Programa de Saúde da Criança e do Adolescente – Universidade Federal do Rio Grande do Sul – UFRGS
  • Ana Cláudia Reis Schneider Instituto de Pesquisas, Ensino e Gestão em Saúde (IPGS)

Keywords:

Obesity, Dysbiosis, Obesogenic microbiota, Inflammation, Probiotic, Prebiotic

Abstract

The knowledge that the composition of intestinal microbiota is different in lean and obese humans indicates that the microbiota plays an important role in the pathophysiology of obesity. Studies show that diet composition promotes the modification of intestinal bacterial species, favoring the increase of energy extraction from the diet, insulin resistance and obesity. Unbalanced diets, with overload fat and low fiber content, lead to increased Firmicutes and Proteobacteria phyla favoring dysbiosis, endotoxemia and inflammation. The use of probiotics, prebiotics and symbiotics, in order to modulate the composition of intestinal microbiome, may be a promising therapy for the reduction of the metabolic complications of obesity; however, further studies should be conducted to establish which probiotic species are suitable to help in the treatment of obesity.

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Published

2015-12-28

How to Cite

1.
Perpétuo JP, Wilasco MI de A, Schneider ACR. The role of intestinal microbiota in energetic metabolism: new perspectives in combating obesity. Clin Biomed Res [Internet]. 2015 Dec. 28 [cited 2025 Jun. 24];35(4). Available from: https://seer.ufrgs.br/index.php/hcpa/article/view/60358

Issue

Vol. 35 No. 4 (2015): Clinical and Biomedical Research

Section

Special Articles

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