Unusual features of oral sarcomatoid carcinoma: a case report
DOI:
https://doi.org/10.22491/2357-9730.138820Keywords:
Sarcomatoid carcinoma, Head and neck cancer, Spindle cell carcinoma, case reportAbstract
Oral sarcomatoid carcinoma (OSC) is considered a rare variant of oral squamous cell carcinoma (OSCC). It is extremely aggressive, affecting mainly older men with risk habits. We report an atypical case of OSC, in a 40-year-old black female that presented an invasive ulceration covering the left hard palate to the ipsilateral buccal mucosa with tissue loss and buccosinusal communication, measuring about 10 x 8 cm. The patient didn’t refer any risk habits. After incisional biopsy, histopathological examination was suggestive for a spindle cell malignant neoplasm. Immunohistochemistry (IHC) revealed positivity for keratins (CK) 7,8/18 and p63 and negativity for calponin, S-100, α-SMA and SOX-10. The patient underwent 9 cycles of chemoterapy, but unfortunately, she died 3 months later. This is an atypical case of OSC, since it usually occurs in older male patients with risk habits. This tumor may lead pathologists to misdiagnosis and IHC is crucial for definitive diagnosis.
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Copyright (c) 2025 Felippe José Almeida Loureiro, Larissa Gabriely Oliveira Cavalcanti, Lauren Frenzel Schuch, Vinicius Coelho Carrard, Luis Fernando da Rosa Rivero, Manoela Domingues Martins, Marco Antonio Trevizani Martins
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