TGF-β1 and its association with clinicopathological features, proliferative activity and prognosis in oral squamous cell carcinoma: An immunohistochemical study

Autores

  • Camila Weissheimer Faculdade de Odontologia Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre. RS, Brasil. Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP). Piracicaba. SP, Brasil.
  • Vivian Petersen Wagner Faculdade de Odontologia Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre. RS, Brasil. Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP). Piracicaba. SP, Brasil.
  • Liana Preto Webber Faculdade de Odontologia Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre. RS, Brasil. Laboratório de Biologia Epitelial, Departamento de Periodontia e Medicina Oral, Faculdade de Odontologia da Universidade de Michigan Ann Arbor. Michigan, Estados Unidos.
  • Manoel Sant’Ana Filho Faculdade de Odontologia Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre. RS, Brasil.
  • Jean Nunes dos Santos Faculdade de Odontologia da Universidade Federal da Bahia (UFBA), Salvador, Bahia, Brasil.
  • Manoela Martins Faculdade de Odontologia Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre. RS, Brasil. Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP). Piracicaba. SP, Brasil.
  • Luise Meurer Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS) . Porto Alegre. RS, Brazil.
  • Marco Antônio Trevizani Martins Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS) . Porto Alegre. RS, Brazil.

Palavras-chave:

Head and neck neoplasms, prognosis, transforming growth factors

Resumo

Introduction: The prognostic value of transforming growth factor beta-1 (TGF-ß1) in oral cancer remains unclear. Therefore, the aim of this study was to evaluate TGF-β1 expression in oral squamous cell carcinoma (OSCC) samples and its association with clinicopathological data, tumor proliferative activity and patients’ prognosis.

Methods: Sixty-eight patients with histopathological diagnosis of OSCC were included, as 9 cases of normal oral mucosa for comparison purposes. OSCC sample was categorized according to patients’ outcomes in favorable prognosis (n=30) or unfavorable prognosis (n=38). Immunohistochemical staining for TGF-β1 and Ki-67 was performed. The slides were semi-quantitatively and quantitatively evaluated for TGF-β1 and Ki-67, respectively.

Results: TGF-β1 was significantly increased in OSCC compared to normal oral mucosa (<0.01). An inverse correlation was found between TGF-β1 and Ki67 staining in OSCC (p=0.01). No association was found between TGF-β1 expression and OSCC clinicopathological features, prognosis or survival.

Conclusion: TGF-β1 had no prognostic value and appears to maintain it’s suppressive role concerning cell proliferation.

 

Keywords: Head and neck neoplasms; prognosis; transforming growth factors 

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Publicado

2019-02-19

Como Citar

1.
Weissheimer C, Wagner VP, Webber LP, Sant’Ana Filho M, dos Santos JN, Martins M, Meurer L, Martins MAT. TGF-β1 and its association with clinicopathological features, proliferative activity and prognosis in oral squamous cell carcinoma: An immunohistochemical study. Clin Biomed Res [Internet]. 19º de fevereiro de 2019 [citado 29º de novembro de 2022];38(4). Disponível em: https://seer.ufrgs.br/index.php/hcpa/article/view/83687

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