Sublingual immunotherapy in the treatment of allergic asthma: a systematic review with meta-analysis

Authors

  • Cristian Roncada Research Center in Child Health - NESC. Institute of Biomedical Research - IPB. Pontifícia Universidade Católica do Rio Grande do Sul – PUCRS. Porto Alegre, RS, Brazil. Biomedical School. Centro Universitário da Serra Gaúcha – FSG. Caxias do Sul, RS, Brazil.
  • Bianca Martininghi Bugança Biomedical School. Centro Universitário da Serra Gaúcha – FSG. Caxias do Sul, RS, Brazil.
  • Karina Soldera Biomedical School. Centro Universitário da Serra Gaúcha – FSG. Caxias do Sul, RS, Brazil.
  • Paulo Márcio Pitrez Research Center in Child Health - NESC. Institute of Biomedical Research - IPB. Pontifícia Universidade Católica do Rio Grande do Sul – PUCRS. Porto Alegre, RS, Brazil.

Keywords:

Mites, asthma, rhinitis, respiratory disease

Abstract

Introduction: The guidelines for the management of allergic respiratory diseases oriented towards control from medical treatment combined with measures of environmental hygiene. Immunotherapy is one of several types of treatment, applied in combination with prophylactic drugs and environmental care. The aim of the study is to evaluate the efficacy of sublingual immunotherapy (SLIT) for house dust mites (HDM) in people with allergic asthma.

Methods: The study is based on a systematic review with meta-analysis of randomized clinical trials, associating sublingual immunotherapy with the treatment of allergic patients with HDM.

Results: The searches were applied in PubMed, ScienceDirect and Scielo databases. Initially, 98 articles were recovered, of which only nine were eligible. Of these, eight (88.9%) were conducted in Europe and only one (11.1%) in Asia. Comparing the outcomes expiratory volume in the first minute (FEV1) and sensitivity to allergens (HDM) between SLIT and placebo groups before and after intervention, no differences were observed between the groups.

Conclusions: SLIT is not evidenced significantly by meta-analysis for the treatment of allergic asthma.

Keywords: Mites; asthma; rhinitis; respiratory disease

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Author Biographies

Cristian Roncada, Research Center in Child Health - NESC. Institute of Biomedical Research - IPB. Pontifícia Universidade Católica do Rio Grande do Sul – PUCRS. Porto Alegre, RS, Brazil. Biomedical School. Centro Universitário da Serra Gaúcha – FSG. Caxias do Sul, RS, Brazil.

Doutor em Saúde da Criança, Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS, Professor do Centro Universitário da Serra Gaúcha – FSG. Caxias do Sul/RS/BR.

Bianca Martininghi Bugança, Biomedical School. Centro Universitário da Serra Gaúcha – FSG. Caxias do Sul, RS, Brazil.

Graduanda em Biomedicina, Centro Universitário da Serra Gaúcha - FSG. Caxias do Sul/RS/BR.

Karina Soldera, Biomedical School. Centro Universitário da Serra Gaúcha – FSG. Caxias do Sul, RS, Brazil.

Graduanda em Biomedicina, Centro Universitário da Serra Gaúcha - FSG. Caxias do Sul/RS/BR.

Paulo Márcio Pitrez, Research Center in Child Health - NESC. Institute of Biomedical Research - IPB. Pontifícia Universidade Católica do Rio Grande do Sul – PUCRS. Porto Alegre, RS, Brazil.

Doutor em Pneumologia, Universidade Federal do Rio Grande do Sul - UFRGS, Professor da Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS. Porto Alegre/RS/BR.

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Published

2017-12-15

How to Cite

1.
Roncada C, Bugança BM, Soldera K, Pitrez PM. Sublingual immunotherapy in the treatment of allergic asthma: a systematic review with meta-analysis. Clin Biomed Res [Internet]. 2017 Dec. 15 [cited 2025 Jun. 25];37(4). Available from: https://seer.ufrgs.br/index.php/hcpa/article/view/74281

Issue

Vol. 37 No. 4 (2017): Clinical and Biomedical Research

Section

Review Articles

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