Posssible enhancement of long-term fear conditioning performance by cisplatin administration in rats
DOI:
https://doi.org/10.22491/2357-9730.25016Keywords:
cisplatin, cancer chemotherapy, memory, cognitive function, animal modelsossiAbstract
Background: Neurocognitive deficits associated with chemotherapy represent an increasing concern, and the development of animal models to investigate chemotherapy-induced alterations in memory is warranted
Aims: To examine the effects of systemic injection of cisplatin on formation of fear-motivated memory in rats.
Methods: Male Wistar rats were given an intraperitoneal (i.p.) injection of saline or cisplatin followed by inhibitory avoidance (IA) training. Memory retention was tested 1 and 7 days after training. Control experiments using an open field were carried out to confirm the specificity of the cisplatin-induced alteration in IA performance.
Results: Cisplatin induced a unexpected enhancement of IA performance measured 7 days after drug injection and training. Control experiments suggested that the effect could not be attributed to sensorimotor alterations or toxic effects.
Discussion: The findings are discussed in the light of previous preclinical evidence that cancer chemotherapy can, under some conditions, lead to memory enhancement.Downloads
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