Proteinuria
clinical and laboratory approach
DOI:
https://doi.org/10.22491/2357-9730.125388Keywords:
Proteinuria, glomerulonephritis, nephrotic syndromeAbstract
Proteinuria is a strong indicator of renal disease and it is present in many syndromes. Our objective is to review the pathophysiological mechanisms that lead to proteinuria, as well as the available methods for its detection and quantitation, including the dipstick, 24-hour proteinuria, and the urinary protein-creatinine ratio. We gave special attention to clinical evaluation of proteinuric patients, including the available exams and the situations in which they are indicated. An algorithm for the investigation of patients with proteinuria is presented. We also emphasized the importance of persistent proteinuria in its relation with the progression of renal diseases.
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