Factors associated to acute renal failure after hepatic transplant
DOI:
https://doi.org/10.22491/2357-9730.124813Keywords:
Acute renal failure, hepatic transplantAbstract
OBJECTIVE: To evaluate the prevalence and the risk factors associated to the development of acute renal failure in patients submitted to liver transplant, at Hospital
de Clínicas de Porto Alegre from September 1996 to September 1998.
PATIENTS AND METHODS: 36 patients that developed acute renal failure after liver transplant (group 1) were compared to those who did not develop acute renal
failure after liver transplant (group 2). The following factors were analyzed prior to surgery: etiology of the renal failure, classification of Child-Pugh, diabetes mellitus,and creatinine levels; during surgery: duration of warm ischemia, duration of surgery, duration of anesthesia; CHAD type of portocaval anastomosis; and after surgery: creatinine levels, infections, need for dialysis, duration of stay at the intensive care unit, cyclosporine levels, need for another intervention, and mortality. All data were evaluated during the first 7 days after surgery, with the exception of chronic renal failure and mortality, which were evaluated during a 3-month period.
RESULTS: The prevalence of acute renal failure was high (approximately 49%). The presence of previous diabetes mellitus (P=0.03), the CHAD units used during
surgery (P=0.046), the duration of stay at the intensive care unit (P=0.01), the surgical technique (P=0,04), and the need for another intervention (P=0.02), were all
significantly associated to the development of acute renal failure after liver transplant in our sample. There was a significant level of mortality among patients that developed acute renal failure (P=0.02).
CONCLUSIONS: We concluded that acute renal failure is a significant cause of mortality among patients submitted to hepatic transplant when associated to multiple
risk factors.
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