Hepcidin serum levels in HCV chronically mono-infected naïve patients, compared to healthy individuals

Authors

  • Ari Ben Hur Stefani Leao Departamento de Gastroenterologia e Endoscopia, Hospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brasil. Pós-Graduação em Gastroenterologia e Hepatologia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre, RS, Brasil
  • Maria da Graça Ferronato Pós-Graduação em Gastroenterologia e Hepatologia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre, RS, Brasil
  • Carlos Kupski Departamento de Gastroenterologia e Endoscopia, Hospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brasil.
  • Fernando Comunello Schacher Departamento de Gastroenterologia e Endoscopia, Hospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brasil. http://orcid.org/0000-0002-6991-1174
  • Denise Cantarelli Machado Laboratório de biologia celular e molecular, Instituto de Pesquisa Biomédica, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS). Porto Alegre, RS, Brasil
  • Mario Reis Álvares-da-Silva Pós-Graduação em Gastroenterologia e Hepatologia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre, RS, Brasil Departamento de Hepatologia, Hospital de Clínicas de Porto Alegre (HCPA). Porto Alegre, RS, Brasil

DOI:

https://doi.org/10.22456/2357-9730.77856

Keywords:

Hepcidin, HCV, interleukin-6 (IL-6), mono-infected

Abstract

Introduction: Metabolism of iron is altered in patients infected with chronically Hepatitis C. The aim of this study is to compare compare the hepcidin levels in between individuais chronically infected with HCV and uninfected individuals. The aim of this study is to compare the hepcidin serum levels between individuals chronically infected with HCV and uninfected individuals.

Methods: A cross-sectional study evaluating hepcidin serum levels of mono-infected HCV (n=29), naive, non-diabetic, non-cirrhotic and non-obese patients by means of ELISA, compared to uninfected patients (n=9) with the same characteristics. The degree of liver fibrosis, according to the METAVIR scale on liver biopsies, the lipid profile, the resistance insulin level, as calculated on HOMA-IR (homeostatic model assessment for insulin resistance), the interleukin-6 (IL-6) and the ferritin serum levels were also measured.

Results: The levels of hepcidin were significantly lower in HCV patients compared to controls (8.4 pg/mL (±4.94) vs. 19.51 pg/mL (±5.51)) with p<0.001. The levels of ferritin and hepcidin did not show any relation. There was no difference between hepcidin levels in relation to viral genotype, viral load, IL-6 and degrees of fibrosis within HCV infected individuals.

Conclusion: It is possible that hepatic iron overload in this population is explained by suppressed levels of hepcidin in patients with HCV.

Keywords: Hepcidin; HCV; interleukin-6 (IL-6); mono-infected

Downloads

Download data is not yet available.

Author Biographies

Ari Ben Hur Stefani Leao, Departamento de Gastroenterologia e Endoscopia, Hospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brasil. Pós-Graduação em Gastroenterologia e Hepatologia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre, RS, Brasil

Médico residente do serviço de Medicina Interna do Hospital de Clínicas de Porto Alegre

Denise Cantarelli Machado, Laboratório de biologia celular e molecular, Instituto de Pesquisa Biomédica, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS). Porto Alegre, RS, Brasil

Laboratório de  biologia celular e molecular, Instituto de Pesquisa Biomédica

Downloads

Published

2018-07-19

How to Cite

1.
Leao ABHS, Ferronato M da G, Kupski C, Schacher FC, Machado DC, Álvares-da-Silva MR. Hepcidin serum levels in HCV chronically mono-infected naïve patients, compared to healthy individuals. Clin Biomed Res [Internet]. 2018 Jul. 19 [cited 2025 Jun. 25];38(2). Available from: https://seer.ufrgs.br/index.php/hcpa/article/view/77856

Issue

Vol. 38 No. 2 (2018): Clinical and Biomedical Research

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

Most read articles by the same author(s)