Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil

Autores

  • Maria Aparecida Andreza Leopoldino Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil
  • Eunice Beatriz Martin Chaves Department of Gynecology and Obstetrics, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
  • Carmem Lúcia Oliveira da Silva Department of Pediatrics, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
  • Helena von Eye Corleta Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

Palavras-chave:

Risk factors, infectious disease transmission, vertical transmission, acquired immunodeficiency syndrome

Resumo

Objective: To evaluate factors that may interfere in mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV).

Method: A historical cohort study with a sample of 299 HIV-infected mothers and their newborns who delivered at the Obstetric Center of the Hospital de Clínicas de Porto Alegre, southern Brazil, from January 2010 to December 2014.

Results: Of the 299 newborns of HIV-infected mothers, 3.7% (n = 11) were infected. Of those, 90.9% (n = 10) were born by cesarean section; 90.9% (n = 10) had ≥ 37 weeks; 54.6% (n = 6) received zidovudine starting within the first 4 hours after birth; and 45.4% (n = 5) received zidovudine and nevirapine. Four women whose newborns were infected with HIV had syphilis during pregnancy (36.4%). Poor adherence to highly active antiretroviral therapy (HAART) (p < 0.003), viral load ≥ 1000 copies/mL or ignored in the third trimester (p < 0.000), and CD4 count < 500 cells/mm3 in the third trimester (p < 0.046) were significantly associated with an increased risk of MTCT.

Conclusion: Lack of control of risk factors may contribute to unfavorable rates of MTCT of HIV.

Keywords: Risk factors; infectious disease transmission; vertical transmission; acquired immunodeficiency syndrome

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Biografia do Autor

Maria Aparecida Andreza Leopoldino, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil

Gynecoloy and Obstetrics

Eunice Beatriz Martin Chaves, Department of Gynecology and Obstetrics, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil

Gynecology and Obstetrics Service

Carmem Lúcia Oliveira da Silva, Department of Pediatrics, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil

Pediatrics Service

Helena von Eye Corleta, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

Gynecology and Obstetrics Service

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Publicado

2017-12-15

Como Citar

1.
Leopoldino MAA, Chaves EBM, da Silva CLO, Corleta H von E. Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil. Clin Biomed Res [Internet]. 15º de dezembro de 2017 [citado 7º de outubro de 2022];37(4). Disponível em: https://seer.ufrgs.br/index.php/hcpa/article/view/73975

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