Posssible enhancement of long-term fear conditioning performance by cisplatin administration in rats

Autores

  • Bruno Kilpp Goulart
  • Algemir Lunardi Brunetto
  • Gilberto Schwartsmann
  • Silvia Ramos Hecktheuer Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, e Laboratório de Pesquisas em Câncer, Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre
  • Gustavo Kellermann Reolon
  • Natasha Maurmann
  • Rafael Roesler

Palavras-chave:

cisplatin, cancer chemotherapy, memory, cognitive function, animal modelsossi

Resumo

Background: Neurocognitive deficits associated with chemotherapy represent an increasing concern, and the development of animal models to investigate chemotherapy-induced alterations in memory is warranted

Aims: To examine the effects of systemic injection of cisplatin on formation of fear-motivated memory in rats.

Methods: Male Wistar rats were given an intraperitoneal (i.p.) injection of saline or cisplatin followed by inhibitory avoidance (IA) training. Memory retention was tested 1 and 7 days after training. Control experiments using an open field were carried out to confirm the specificity of the cisplatin-induced alteration in IA performance.

Results: Cisplatin induced a unexpected enhancement of IA performance measured 7 days after drug injection and training. Control experiments suggested that the effect could not be attributed to sensorimotor alterations or toxic effects.

Discussion: The findings are discussed in the light of previous preclinical evidence that cancer chemotherapy can, under some conditions, lead to memory enhancement.

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Biografia do Autor

Silvia Ramos Hecktheuer, Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, e Laboratório de Pesquisas em Câncer, Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre

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Publicado

2012-01-27

Como Citar

1.
Goulart BK, Brunetto AL, Schwartsmann G, Hecktheuer SR, Reolon GK, Maurmann N, Roesler R. Posssible enhancement of long-term fear conditioning performance by cisplatin administration in rats. Clin Biomed Res [Internet]. 27º de janeiro de 2012 [citado 27º de novembro de 2022];31(4). Disponível em: https://seer.ufrgs.br/index.php/hcpa/article/view/25016

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