Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12
DOI:
https://doi.org/10.22491/2357-9730.123482Keywords:
diabetes mellitus, metformina, vitamina B12Abstract
Diabetes Mellitus is a metabolic disease characterized by absolute or relative insulin deficiency, which affects about 382 million people, and it may have as a complication the Polyneuropathy. Vitamin B12 deficiency is also related to the development of polyneuropathy, and some literature describe that Metformin, a medicinal product widely used for diabetes control, may aggravate or even cause this deficiency. So, a study was conducted in Soledade - RS, aiming to verify whether this relationship is related to the reality of the locality. 58 patients were chosen, 30 of them answered adapted questionnaires based on the literature and the Michigan Neuropathy Classification (MNSS-Brazil), then collected 5 ml of venous blood from the antecubital fossa, and an aliquot from prepared serum to biochemical determination of vitamin B12. Analyzing the results, no variable explained the correlation between chronic use of Metformin to vitamin B12 deficiency, which indicates that there is not enough evidence to support this fact, according to the particularities of the locality analyzed.
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Copyright (c) 2023 Liliane de Jesus Mattos, Júlia Breitenbach Diniz, Luciano de Oliveira Siqueira
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