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A COMPLETE NMR STUDY OF DOXAZOSIN CHARACTERIZATION

Authors

  • Itamar Luís Gonçalves Laboratório de Síntese Orgânica Medicinal/LaSOM, Programa de Pós-Graduação em Ciências Farmacêuticas/PPGCF, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre-RS, Brazil http://orcid.org/0000-0001-5952-6291
    • Mariana Maier Gaelzer Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil,
      • Gabriel Oliveira de Azambuja aLaboratório de Síntese Orgânica Medicinal/LaSOM, Programa de Pós-Graduação em Ciências Farmacêuticas/PPGCF, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre-RS, Brazil
        • Christianne Gazzana Salbego Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil
          • Vera Lucia Eifler-Lima Laboratório de Síntese Orgânica Medicinal/LaSOM, Programa de Pós-Graduação em Ciências Farmacêuticas/PPGCF, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre-RS, Brazil

            DOI:

            https://doi.org/10.22456/2527-2616.73960

            Abstract

            Doxazosin is an important drug used for treating hypertension and prostatic hyperplasia. An enantiomeric mixture (R)/(S) doxazosin mesylate was complete characterized by NMR and additionally FT-IR spectroscopy techniques. Were performed different NMR experiments, such as APT, HSQC, and HMBC in order to confirm the NMR signals assignments. All the hydrogens and the most of carbons atoms were assigned. 

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            Published

            28-08-2017

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            How to Cite

            Gonçalves, I. L., Maier Gaelzer, M., Oliveira de Azambuja, G., Gazzana Salbego, C., & Eifler-Lima, V. L. (2017). A COMPLETE NMR STUDY OF DOXAZOSIN CHARACTERIZATION. Drug Analytical Research, 1(1), p. 56–60. https://doi.org/10.22456/2527-2616.73960

            Issue

            Vol. 1 No. 1 (2017)

            Section

            ORIGINAL ARTICLES

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            Copyright (c) 2017 Drug Analytical Research

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