A complete study of Doxazosin characterization
DOI:
https://doi.org/10.22456/2527-2616.73960Keywords:
doxazosin, NMR, FT-IR, signals assignmentAbstract
Doxazosin is an important drug used to treat hypertension and prostatic hyperplasia. An enantiomeric (R)/(S) doxazosin
mesylate mixture was complete characterized by NMR and additionally FT-IR spectroscopy techniques. Different NMR
experiments were performed, such as APT, HSQC, and HMBC in order to confirm the NMR signals assignments. All the
hydrogens and most of carbons atoms were assigned. In this context, the results reported here, consists in important
information for identification and quality control of doxazosin mesylate.
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References
Wykretowicz, A., Guzik, P., Wysocki, H. Doxazosin in the current treatment of hypertension. Expert opinion on pharmacotherapy. 2008;9(4):625-33.
Wilt, T.J., MacDonald, R. Doxazosin in the treatment of benign prostatic hypertrophy: an update. Clinical interventions in aging. 2006;1(4):389.
Pfizer. Company History 2017 [cited 2017 20/07/2017]. Available from: http://www.pfizer.com/about/history/all.
Gaelzer, M.M., Coelho, B.P., de Quadros, A.H., Hoppe, J.B., Terra, S.R., Guerra, M.C.B., et al. Phosphatidylinositol 3-Kinase/AKT pathway inhibition by doxazosin promotes glioblastoma cells death, upregulation of p53 and triggers low neurotoxicity. PloS one. 2016;11(4):e0154612.
Pantziarka, P., Bouche, G., Meheus, L., Sukhatme, V., Sukhatme, V.P., Vikas, P. The repurposing drugs in oncology (ReDO) project. ecancermedicalscience. 2014;8.
González-Juanatey, J.R., Iglesias, M.J., Alcaide, C., Piñeiro, R., Lago, F. Doxazosin induces apoptosis in cardiomyocytes cultured in vitro by a mechanism that is independent of α 1-adrenergic blockade. Circulation. 2003;107(1):127-31.
Nikolic, K., Filipic, S., Smoliński, A., Kaliszan, R., Agbaba, D. Partial least square and hierarchical clustering in ADMET modeling: Prediction of blood– brain barrier permeation of α-adrenergic and imidazoline receptor ligands. Journal of Pharmacy & Pharmaceutical Sciences. 2013;16(4):622-47.
Bakshi, M., Ojha, T., Singh, S. Validated specific HPLC methods for determination of prazosin, terazosin and doxazosin in the presence of degradation products formed under ICH-recommended stress conditions. Journal of Pharmaceutical and Biomedical Analysis. 2004;34(1):19-26.
Yuan, X-R., Liu, Y-H., Li, R-Y., Chen, X-X. Experimental and theoretical NMR study of (s)- doxazosin. Acta Physico-Chimica Sinica. 2008;24(6):1058-62.
Loidreau, Y., Besson, T. Microwave-assisted thermal decomposition of formamide: a tool for coupling a pyrimidine ring with an aromatic partner. Tetrahedron. 2011;67(26):4852-7.
Rouf, A., Aga, M.A., Kumar, B., Taneja, S.C. A facile approach to chiral 1, 4-benzodioxane toward the syntheses of doxazosin, prosympal, piperoxan, and dibozane. Tetrahedron Letters. 2013;54(48):6420-2.
Tsyskovskaia, I., Kandil, M., Beaumier, Y. Synthesis of a New Doxazosin‐Related Compound. Synthetic communications. 2007;37(3):447-50.
Zhang, L-Y., Wang, B-L., Zhan, Y-Z., Zhang, Y., Zhang, X., Li, Z-M. Synthesis and biological activities of some fluorine- and piperazine-containing 1,2,4- triazole thione derivatives. Chinese Chemical Letters. 2016;27(1):163-7.
Koester, L.S., Guterres, S.S., Le Roch, M., EiflerLima, V.L., Zuanazzi, J.A., Bassani, V.L. Ofloxacin/βCyclodextrin Complexation. Drug Development and Industrial Pharmacy. 2001;27(6):533-40.
Commission BP. British Pharmacopoeia. London2013.
Pharmacopeia U. United States Pharmacopeia. The Standard USA: US Pharmacopeia 1995. 2002.
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