A COMPLETE NMR STUDY OF DOXAZOSIN CHARACTERIZATION

Authors

  • Itamar Luís Gonçalves Laboratório de Síntese Orgânica Medicinal/LaSOM, Programa de Pós-Graduação em Ciências Farmacêuticas/PPGCF, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre-RS, Brazil http://orcid.org/0000-0001-5952-6291
  • Mariana Maier Gaelzer Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil,
  • Gabriel Oliveira de Azambuja aLaboratório de Síntese Orgânica Medicinal/LaSOM, Programa de Pós-Graduação em Ciências Farmacêuticas/PPGCF, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre-RS, Brazil
  • Christianne Gazzana Salbego Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil
  • Vera Lucia Eifler-Lima Laboratório de Síntese Orgânica Medicinal/LaSOM, Programa de Pós-Graduação em Ciências Farmacêuticas/PPGCF, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre-RS, Brazil

DOI:

https://doi.org/10.22456/2527-2616.73960

Abstract

Doxazosin is an important drug used for treating hypertension and prostatic hyperplasia. An enantiomeric mixture (R)/(S) doxazosin mesylate was complete characterized by NMR and additionally FT-IR spectroscopy techniques. Were performed different NMR experiments, such as APT, HSQC, and HMBC in order to confirm the NMR signals assignments. All the hydrogens and the most of carbons atoms were assigned. 

Downloads

Download data is not yet available.

Downloads

Published

2017-08-28

How to Cite

Gonçalves, I. L., Maier Gaelzer, M., Oliveira de Azambuja, G., Gazzana Salbego, C., & Eifler-Lima, V. L. (2017). A COMPLETE NMR STUDY OF DOXAZOSIN CHARACTERIZATION. Drug Analytical Research, 1(1), p. 56–60. https://doi.org/10.22456/2527-2616.73960

Issue

Vol. 1 No. 1 (2017)

Section

ORIGINAL ARTICLES

License

The Copyright holder of manuscripts published is Drug Analytical Research. Authors who publish with this journal are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.


Licensing:

Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License

Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author.