TGF-β1 and its association with clinicopathological features, proliferative activity and prognosis in oral squamous cell carcinoma: An immunohistochemical study

Camila Weissheimer, Vivian Petersen Wagner, Liana Preto Webber, Manoel Sant’Ana Filho, Jean Nunes dos Santos, Manoela Martins, Luise Meurer, Marco Antônio Trevizani Martins


Introduction: The prognostic value of transforming growth factor beta-1 (TGF-ß1) in oral cancer remains unclear. Therefore, the aim of this study was to evaluate TGF-β1 expression in oral squamous cell carcinoma (OSCC) samples and its association with clinicopathological data, tumor proliferative activity and patients’ prognosis.

Methods: Sixty-eight patients with histopathological diagnosis of OSCC were included, as 9 cases of normal oral mucosa for comparison purposes. OSCC sample was categorized according to patients’ outcomes in favorable prognosis (n=30) or unfavorable prognosis (n=38). Immunohistochemical staining for TGF-β1 and Ki-67 was performed. The slides were semi-quantitatively and quantitatively evaluated for TGF-β1 and Ki-67, respectively.

Results: TGF-β1 was significantly increased in OSCC compared to normal oral mucosa (<0.01). An inverse correlation was found between TGF-β1 and Ki67 staining in OSCC (p=0.01). No association was found between TGF-β1 expression and OSCC clinicopathological features, prognosis or survival.

Conclusion: TGF-β1 had no prognostic value and appears to maintain it’s suppressive role concerning cell proliferation.


Keywords: Head and neck neoplasms; prognosis; transforming growth factors 


Head and neck neoplasms; prognosis; transforming growth factors

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ISSN: 2357-9730




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