Evaluation of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as biomarkers in patients with diabetes mellitus and/or systemic arterial hypertension
DOI:
https://doi.org/10.22491/2357-9730.154876Keywords:
Cardiovascular Diseases, Hypertension, Diabetes Mellitus, Inflammation, BiomarkersAbstract
Introduction: Cardiovascular diseases (CVD) are major cause of morbidity and mortality in individuals with diabetes mellitus (DM) and systemic arterial hypertension (SAH). Recent studies have revealed a significant association between neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios with an increased risk of CVD in individuals with DM and SAH. This study aims to compare the relationships between RNL and RPL in groups of users in primary health care. Methods: This is a retrospective study developed from 244 blood counts of patients of both sexes over 18 years of age, divided into 4 groups: healthy, SAH, DM, SAH + DM. NLR and PLR ratios were tabulated, data presented as mean ± and standard deviation and compared using non-parametric tests, with a p-value <0.05 considered. Results: The NLR analysis showed an increase in the DM group (mean 2.444, median 2.275) compared to the CONTROL group (mean 1.851, median 1.681) and the HAS+DM group (mean 1.832 and median 1.618), with p = 0.0335 and 0.0179, respectively. Regarding the PLR, an increasing trend was observed in the CONTROL group (mean 132.4 and median 127.9) compared to the HAS group (mean 117.6 and median 111.4) and the HAS+DM group (mean 119.6 and median 109.6), with p = 0.0059 and 0.0231, respectively. Discussion: The study demonstrated that NLR is statistically relevant in diabetic and diabetic-hypertensive patients, and PLR is statistically relevant in hypertensive and diabetic-hypertensive patients, representing an important and easily obtainable biomarker of disease.
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Copyright (c) 2026 Bárbara Rocha Rodrigues Cox Coelho, Lucas Mendes Reis de Moura, Rodrigo Mendes, Pedro Pereira Tenório
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