Clinical evolution, transfusion reactions, and transfusion safety in recipients of blood components from donors with positive serology and/or positive PCR results for SARS-CoV-2
DOI:
https://doi.org/10.22491/2357-9730.153782Keywords:
COVID-19, Hemotherapy, SARS-CoV-2, Transfusion safetyAbstract
Introduction: The COVID-19 pandemic has raised concerns about the possibility of virus transmission via blood transfusions. This study aimed to verify the safety of transfusing blood components from donors with positive SARS-CoV-2 serology and/or detectable PCR in serum. Methods: An analytical, longitudinal, and retrospective cohort study was conducted using 208 serum samples from blood donations collected from January to March 2021 at a Brazilian blood bank. After initial screening with a rapid test, samples were divided into a Test Group (TG), with 98 samples positive for SARS-CoV-2, and a Control Group (CG), with 110 negative samples. We collected donor demographic data, tracked blood components, and evaluated recipients regarding their demographic profile, hospitalization data, transfusion reactions, and SARS-CoV-2 test results up to 28 days after transfusion. Results: In the TG, 50% of samples were IgM positive and 97% were IgG positive. In total, 381 blood components were transfused in 217 transfusion procedures to 124 recipients. The recipients had a mean age of 43.4 years, with 49.2% in clinical beds and a median hospital stay of 28 days. The frequency of transfusion reactions was 2.3%, and 16.9% of cases presented with dyspnea/desaturation, with no significant difference between groups. Conclusion: In conclusion, we found no differences in transfusion outcomes between groups, as well as no evidence of transfusion-transmitted SARS-CoV-2 cases.
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Copyright (c) 2026 Moniky Brito Silva Bulhões, Bruna Martins Schweinberger, Carolina Rodrigues Cohen, Carolina Vaccari Batista, Elissandra Machado Arlindo de Mattos, Francine Bonacina, Gabriel Giron Correa, Gabriela Pasqualim, Janaína Aparecida Risczik Arruda Corrêa, João Vitor Barboza Cardoso, Renata Eliane Boehm , Leo Sekine, Bruno Dutra Arbo
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