Hemophilia throughout the life cycle


  • Dayenne H. Catelli Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil https://orcid.org/0000-0003-3053-9704
  • Ebellins T. Calvache Dr https://orcid.org/0000-0003-2368-1622
  • Julia P. Portich Hospital de Clínicas de Porto-Alegre, Porto Alegre, Brasil
  • Cristiane S. Weber Hospital de Clínicas de Porto-Alegre, Porto Alegre, Brasil
  • Daniel S. Hoffmann Universidade Estadual do Rio Grande do Sul, Guaíba, Brasil https://orcid.org/0000-0002-9839-3986
  • Guilherme R. Bosi Universidade de Caxias do Sul (UCS), Porto Alegre, Brasil
  • Leo Sekine Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil
  • Lucia MR Silla


hemofilia, ciclo de vida, inibidores


Hemophilia is an inherited X-linked coagulopathy defined by a deficiency or abnormality in the clotting function of factor VIII (hemophilia A) or factor IX (hemophilia B). The continuous improvement of the treatment has made it possible to monitor the patient through their life cycle with the inherent transition of care, initially by caregivers in childhood and later by the patient himself. Alterations associated with age added to chronic diseases are a constant challenge in the comprehensive treatment of the patient. The inhibitors are IgG alloantibodies directed to exogenous clotting factors, factor VIII or factor IX. The likelihood of developing inhibitors varies from one person with hemophilia to another and depends on the interaction between multiple genetic and environmental factors. This review offers a better understanding of the physiological alterations that allow a comprehensive assessment of the patient with hemophilia.


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Como Citar

Catelli DH, Tabares Calvache E, Plentz Portich J, Seganfredo Weber C, Sander Hoffmann D, Rasia Bosi G, Sekine L, Mariano da Rocha Silla L. Hemophilia throughout the life cycle. Clin Biomed Res [Internet]. 29º de novembro de 2023 [citado 29º de fevereiro de 2024];43(3). Disponível em: https://seer.ufrgs.br/index.php/hcpa/article/view/126992



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