Hepatitis C and nephropathy
DOI:
https://doi.org/10.22491/2357-9730.125380Keywords:
Hepatitis C, nephropathy, asymptomatic urinary abnormalitiesAbstract
OBJECTIVE: Many studies have associated hepatitis C virus infection with extra-hepatic manifestations, including glomerulopathies. Our objective is to present a brief review of the literature regarding renal manifestations of hepatitis C and the summarized results from a study aimed at evaluating the association of asymptomatic urinary abnormalities in anti-HCV positive blood donors.
MATERIALS AND METHODS: We carried out a cross- ectional, contemporary, controlled, open study from July 1997 to March 1998 at the Nephrology Services at Hospital de Clínicas de Porto Alegre in order to evaluate the prevalence of asymptomatic urinary abnormalities in hepatitis-C virus carriers. We included 58 blood donors positive for HCV and 128 donors negative for HCV (control group) without history of hepatic or renal disease and without other positive viral markers. We assessed prevalence of hematuria (> 5 red blood cells per high power field in urinary sediment); proteinuria (1 dipstick positive); microalbuminuria (microalbuminuria/creatinine ratio from an isolated sample >15.6 mg/g); and N-acetyl-beta-lucosaminidase (> 5.6 U/g creatinine).
RESULTS: The data showed that the group positive for anti-HCV did not present significant urinary abnormalitiies when compared to a control group. The prevalence of hematuria and proteinuria in the HCV+ e HCV- groups was, respectively, 12.0% x 9.4% and 5.4% x 5.6% with no statistically significant differences.
CONCLUSION: The prevalence of hematuria was similar to that found in the general
population (3-20%).
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