Relationship between Helicobacter pylori infection and metabolic diseases: an integrative review

Relationship between Helicobacter pylori infection and metabolic diseases

Authors

  • Felipe Augusto de Sousa Moraes Faculdade de Farmácia, Universidade Federal de Goiás. Goiânia, GO, Brasil.
  • Gabriel Ribeiro Maximo Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás. Goiânia, GO, Brasil. https://orcid.org/0000-0003-2893-2777
  • Giovana Alice Sampaio Soares Faculdade de Farmácia, Universidade Federal de Goiás. Goiânia, GO, Brasil.
  • Mônica Santiago Barbosa Universidade Federal de Goiás

Keywords:

Helicobacter pylori; Extragastric diseases; Metabolic diseases; Diabetes; Metabolic syndrome.

Abstract

Helicobacter pylori is a Gram-negative bacterium that affects about 50% of the world population. The H. pylori infection is associated with some gastric diseases. However, more recent studies have demonstrated the etiology of the microorganism in extra gastric diseases, such as metabolic diseases. The objective of this work was to conduct a search in the literature of articles that evaluated the association of H. pylori infection with metabolic diseases, with a focus on diabetes and metabolic syndrome (MS). The following databases were used, PubMed, Medline, LILACS and SciElo. Combined terms were used together with the Boolean operator “AND” in Portuguese and English. The result of the bibliographic survey totaled 31 articles. H. pylori infection is possibly related to diabetes and MS. The relationship may be due to chronic inflammation, reduced gastrointestinal movements, lack of secretion of gastric acid and interference in the production or secretion of some hormones. Although studies show that the eradication of the microorganism favors the improvement of glycemic indexes and that infected individuals had a higher prevalence of MS, more research is required. The understanding of the etiology of H. pylori infection in metabolic diseases, can assist in public policies for the eradication of the bacterium.

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Author Biographies

Felipe Augusto de Sousa Moraes , Faculdade de Farmácia, Universidade Federal de Goiás. Goiânia, GO, Brasil.

Bachelor in Biomedicine, graduated from the Federal University of Goiás (UFG). He worked as a monitor of General Microbiology with emphasis on Bacteriology at the Institute of Tropical Pathology and Public Health (IPTSP) at UFG. He worked as a student of Voluntary Scientific Initiation in Bacteriology at IPTSP. Author of two e-books, namely, Practical Classes in Human Bacteriology and Practical Classes in Basic Bacteriology, published by the Integrated Center for Network Learning at UFG (CIAR-UFG). He is currently part of the Helicobacter pylori Study Center (NEHP).

Gabriel Ribeiro Maximo, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás. Goiânia, GO, Brasil.

Graduating in Biotechnology at the Federal University of Goiás. Participates in the Helicobacter pylori Study Center - NEHP as a student of the Institutional Scientific Initiation Scholarship Program. Interested in Microbiology, Molecular Biology and Nanotechnology

Giovana Alice Sampaio Soares, Faculdade de Farmácia, Universidade Federal de Goiás. Goiânia, GO, Brasil.

Bachelor in Biomedicine from the Federal University of Goiás (UFG). Worked as a monitor of General Microbiology (IPTSP/UFG). He was a member of the Board of the Academic League of Neuropsychobiology Education (LAEN). He is currently part of the Helicobacter pylori Study Center (NEHP).

Mônica Santiago Barbosa, Universidade Federal de Goiás

Graduada em Biomedicina pela Universidade Federal de Goiás. Mestrado em Biologia pela Universidade Federal de Goiás. Doutorado em Ciências Biológicas pelo Instituto de Biologia da Universidade de Brasília (UnB), com ênfase em Biotecnologia de microrganismo. Durante seu doutoramento realizou pesquisa de antígenos visando diagnóstico e produção de vacinas recombinantes, com vários artigos publicados em revista de impacto internacional. Atualmente desenvolve projetos utilizando ferramentas da biotecnologia no estudo da bactéria patogênica humana Helicobacter pylori, com artigos publicados em revistas científicas e trabalhos apresentados em congressos nacionais e internacionais, atuando principalmente nos seguintes temas: Antígenos, Vacinas, Expressão Heteróloga de Proteínas. Foi Professora contratada da Universidade Estadual de Goiás (UEG) e Professora efetiva do Centro Universitário de Goiás (UNI-Anhanguera), Faculdade Araguaia e Faculdade Tamandaré. Também foi Professora-Substituta de Genética Molecular da Universidade Federal de Goiás (ICB-UFG)- Campus: Goiânia. Atualmente é professora Associada da Universidade Federal de Goiás - IPTSP.

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Published

2023-09-05

How to Cite

1.
Augusto de Sousa Moraes F, Ribeiro Maximo G, Sampaio Soares GA, Barbosa MS. Relationship between Helicobacter pylori infection and metabolic diseases: an integrative review: Relationship between Helicobacter pylori infection and metabolic diseases. Clin Biomed Res [Internet]. 2023 Sep. 5 [cited 2025 May 10];43(2). Available from: https://seer.ufrgs.br/index.php/hcpa/article/view/125129

Issue

Vol. 43 No. 2 (2023): Clinical and Biomedical Research

Section

Review Articles

License

Copyright (c) 2023 Sr, Sr, Sra, Mônica Santiago Barbosa

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