Environmental risk factors associated with biliary atresia in Rio Grande do Sul, Brazil

Authors

  • Larisse Longo 1- Experimental Laboratory of Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil. 2. Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
  • Jéssica Tonin Ferrari Experimental Laboratory of Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil. Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
  • Giovana Regina Weber Hoss Experimental Laboratory of Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.
  • Leila Xavier Sinigaglia Fratta Experimental Laboratory of Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil
  • Sandra Maria Gonçalves Vieira Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. Pediatric Hepatology Unit, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.
  • Themis Reverbel da Silveira Experimental Laboratory of Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil. Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
  • Fernando Antônio de Abreu e Silva Pediatric Pneumology Unit, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.
  • Maria Teresa Vieira Sanseverino Medical Genetics Service, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil. Faculty of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
  • Jorge Luiz dos Santos Experimental Laboratory of Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil. Faculty of Health Sciences, Health Sciences Research Centre (CICS-UBI), University of Beira Interior, Covilhã, Portugal.

DOI:

https://doi.org/10.22491/2357-9730.71572

Keywords:

Biliary atresia, environmental risk factor, etiology, seasonality, smoking

Abstract

Biliary atresia (BA) seems to be a multifactorial disorder in which environmental factors interact with the patient’s genetic constitution. This study aimed to analyze information concerning environmental risk factors associated with BA in southern Brazil. A case-control study with mothers of patients with BA and mothers of patients with cystic fibrosis (CF) was conducted. Inquiry included questions related to exposition to environmental risk factors during the periconceptional and gestational (second and third trimesters) periods. Mothers of BA patients had smoked during pregnancy more frequently in comparison with the mothers of CF patients, but no significant difference was found in a multivariate analysis. There was no between group difference in terms of seasonality, but the multivariate analysis showed a significant difference within the BA group between date of conception in winter compared to other seasons. In conclusion, smoking during pregnancy seemed to increase the risk of BA while date of conception in winter decreased it.

Keywords: Biliary atresia; environmental risk factor; etiology; seasonality; smoking

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Published

2017-07-17

How to Cite

1.
Longo L, Ferrari JT, Hoss GRW, Fratta LXS, Vieira SMG, da Silveira TR, et al. Environmental risk factors associated with biliary atresia in Rio Grande do Sul, Brazil. Clin Biomed Res [Internet]. 2017 Jul. 17 [cited 2025 Aug. 11];37(2). Available from: https://seer.ufrgs.br/index.php/hcpa/article/view/71572

Issue

Vol. 37 No. 2 (2017): Clinical and Biomedical Research

Section

Brief Communication

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