Thyroid Hormones and Testicular Function
DOI:
https://doi.org/10.22491/2357-9730.3090Keywords:
hormônio tireoidiano, tireóide, metabolismo, função testicular, pesquisa experimentalAbstract
Thyroid hormones play an important role in the growth, development, and metabolism of mammalian tissues. The pro-hormone thyroxine (T4) is synthesized and secreted by the thyroid gland together with a small amount of the active hormone, triiodothyronine (T3). The iodothyronine deiodinases types 1 and 2 catalize the peripheral T4 to T3 conversion. To exert its biological effects T3 interact with specific membrane transporters and nuclear receptors, thus activating gene transcription. Classically, male gonads were considered to be unresponsive to thyroid hormones. Recent studies, however, have shown that thyroid hormones have a critical role in the male reproductive system, not only during development, but also in adult life. Hence, we review and discuss the most recent advances in our understanding of thyroid hormone effects in male gonadal function.Downloads
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