Serum concentration of type III aminoterminal procollagen as a marker of hepatic fibrosis in infants with chronic hepatitis
DOI:
https://doi.org/10.22491/2357-9730.125027Keywords:
Chronic hepatopathy, fibrosis, infants, choice of methodAbstract
OBJECTIVE: To compare type III aminoterminal procollagen serum levels with the histological hepatic study of infants with hepatitis.
PATIENTS AND METHODS: We evaluated 38 patients, with ages that ranged from 5 to 104 weeks, and who had chronic hepatitis caused by different reasons. The
histological analysis was carried out according to Knodell’s score.
RESULTS: Four patients had a Knodell score of 0, 11 patients had a Knodell score of 1, 20 patients had a Knodell score of 2, and three patients had a Knodell score of 4. The levels of type III aminoterminal procollagen increased in 12 patients, decreased
in 10 other patients, and were normal, for the respective age range of the patient, in the remaining 16 patients. The result of the statistical analysis of the comparison
between type III aminoterminal procollagen and fibrosis was P=0.549, with Spearman’s correlation test -0.25. The odds ratio was 1.47, which correlates high levels of type III aminoterminal procollagen with fibrosis.
CONCLUSION: We concluded that type III aminoterminal procollagen is not an adequate
marker for hepatic fibrosis in infants. Histological analysis remains the method of choice.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
