LC-MS/MS METHOD FOR THE SIMULTANEOUS DETERMINATION OF CEFEPIME AND TAZOBACTAM IN DOG PLASMA

Authors

  • Kiran R. Patil Wockhardt Research Centre, D-4, Chikalthana MIDC, Aurangabad-431006, India
  • Sukanta K. Naik Wockhardt Research Centre
  • Vineet S. Zope Wockhardt Research Centre
  • Rajesh P. Chavan Wockhardt Research Centre
  • Ravindra D. Yeole

DOI:

https://doi.org/10.22456/2527-2616.84357

Abstract

A high performance liquid chromatography (HPLC) method with tandem mass spectrometric detection (MS/MS) has been developed and validated for the simultaneous quantification of cefepime and tazobactam in dog plasma. The method was developed on amide column with isocratic elution. The developed method is simple and economic in terms of sample preparation. The method is specific, sensitive, accurate, precise and robust. The method was successfully applied for pre-clinical pharmaco-kinetic studies in dogs. The Tmax was found to be 0.5 hr, the mean Cmax and AUC(0-12) displayed dose proportionate response.

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Author Biography

Kiran R. Patil, Wockhardt Research Centre, D-4, Chikalthana MIDC, Aurangabad-431006, India

Drug Discovery Analytical

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Published

2018-09-14

How to Cite

Patil, K. R., Naik, S. K., Zope, V. S., Chavan, R. P., & Yeole, R. D. (2018). LC-MS/MS METHOD FOR THE SIMULTANEOUS DETERMINATION OF CEFEPIME AND TAZOBACTAM IN DOG PLASMA. Drug Analytical Research, 2(1), p. 36–45. https://doi.org/10.22456/2527-2616.84357

Issue

Vol. 2 No. 1 (2018)

Section

ORIGINAL ARTICLES

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