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UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE DETERMINATION OF BILASTINE USING EXPERIMENTAL DESIGN FOR ROBUSTNESS

Authors

  • Andressa Tassinari da Silva
    • Gabriela Rossi Brabo
      • Isadora Dias Marques
        • Lisiane Bajerski
          • Marcelo Donadel Malesuik
            • Clésio Soldateli Paim

              DOI:

              https://doi.org/10.22456/2527-2616.79221

              Abstract

              Bilastine is a novel nonsedative H1-receptor antagonist, which may be used for the symptomatic treatment of chronic idiopathic urticaria (CU). This study describes the validation of an UV spectrophotometric method for quantitative determination of bilastine in tablets using 0.1 mol L-1 HCl as solvent. The method was specific, linear, precise, exact and robust at 210 nm, confirming that the method is fast and useful to the routine quality control of bilastine in tablets. The validate method was compared to liquid chromatography (HPLC), which was previously developed and validated to the same drug, and no significative difference between the methods using Student´s t test was found to bilastine quantitation.

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              Published

              28-12-2017

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              How to Cite

              Tassinari da Silva, A., Rossi Brabo, G., Dias Marques, I., Bajerski, L., Donadel Malesuik, M., & Soldateli Paim, C. (2017). UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE DETERMINATION OF BILASTINE USING EXPERIMENTAL DESIGN FOR ROBUSTNESS. Drug Analytical Research, 1(2), p. 38–43. https://doi.org/10.22456/2527-2616.79221

              Issue

              Vol. 1 No. 2 (2017)

              Section

              ORIGINAL ARTICLES

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