Chemical composition and antimycotic potential of basil, rosemary, clove and cinnamon essential oils against Trichophyton rubrum and Trichophyton mentagrophytes

Patrícia Abreu Pereira; Jade André de Souza; Luiza Bernardes Chagas; Juliana Butzge; Alexandre  Meneguello Fuentefria; Adelina Mezzari †; Miriam Anders Apel

doi:10.22456/2527-2616.140970

Authors

Patrícia Abreu Pereira Programa de Pós-Graduação em Ciências Farmacêuticas (PPGCF) - Universidade Federal do Rio Grande do Sul https://orcid.org/0000-0002-2699-482X
Jade André de Souza Programa de Pós-Graduação em Ciências Farmacêuticas (PPGCF) - Universidade Federal do Rio Grande do Sul https://orcid.org/0000-0002-5447-4928
Luiza Bernardes Chagas Programa de Pós-Graduação em Ciências Farmacêuticas (PPGCF) - Universidade Federal do Rio Grande do Sul https://orcid.org/0009-0004-2271-2559
Juliana Butzge Programa de Pós-Graduação em Ciências Farmacêuticas (PPGCF) - Universidade Federal do Rio Grande do Sul
Alexandre Meneguello Fuentefria Programa de Pós-Graduação em Ciências Farmacêuticas (PPGCF) - Universidade Federal do Rio Grande do Sul https://orcid.org/0000-0003-2979-4417
Adelina Mezzari † Faculdade de Farmácia - Universidade Federal do Rio Grande do Sul
Miriam Anders Apel Programa de Pós-Graduação em Ciências Farmacêuticas (PPGCF) - Universidade Federal do Rio Grande do Sul https://orcid.org/0000-0003-1288-2293

DOI:

https://doi.org/10.22456/2527-2616.140970

Keywords:

Onychomycosis, essential oils, antifungal, Trichophyton

Abstract

Onychomycosis is a disease caused by fungi that affects the nails whose incidence is becoming increasingly frequent. The present study aimed the evaluation of the antifungal activity of essential oils from clove (Syzygium aromaticum), Chinese cinnamon (Cinnamomum cassia), rosemary (Rosmarinus officinalis) and basil (Ocimum basilicum), against the most prevalent dermatophytes implicated in onychomycosis: Trichophyton rubrum and Trichophyton mentagrophytes. The chemical composition of the oils was determined by GC-MS. The volatile oil of clove and Chinese cinnamon and basil presented, respectively, the phenylpropanoids eugenol (80.2%), E-cinnamaldehyde (99.4%) and methyl chavicol (68.81%) as the main components. The volatile oil of rosemary exhibited 1,8-cineole and camphor as the major compounds, representing 47% and 15% of the total content, respectively. The results obtained in broth microdilution tests indicate that basil oil presented the best antifungal potential against the tested strains of Trichophyton rubrum and Trichophyton mentagrophytes at concentrations that ranged from 8 mg/mL to 2 mg/mL. These findings point to the potential prospecting of Ocimum basilicum essential oil as a promising source of natural antimycotics to be subjected for further investigations.

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