Development of calcium alginate beads containing paclitaxel-loaded lipid-core nanocapsules intended for oral administration

Taiane Medeiro Ciocheta; Aline  de Cristo Soares Alves; Danieli Rosane Dallemole; Rodrigo Cé; Silvia Stanisçuaski Guterres; Adriana Raffin Pohlmann

doi:10.22456/2527-2616.122299

Authors

Taiane Medeiro Ciocheta Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia - Universidade Federal do Rio Grande do Sul
Aline de Cristo Soares Alves Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia - Universidade Federal do Rio Grande do Sul
Danieli Rosane Dallemole Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia - Universidade Federal do Rio Grande do Sul
Rodrigo Cé Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia - Universidade Federal do Rio Grande do Sul
Silvia Stanisçuaski Guterres Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia - Universidade Federal do Rio Grande do Sul
Adriana Raffin Pohlmann Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia - Universidade Federal do Rio Grande do Sul

DOI:

https://doi.org/10.22456/2527-2616.122299

Keywords:

Calcium alginate beads, lipid-core nanocapsules, paclitaxel, cancer

Abstract

We developed a solid formulation of calcium alginate beads containing paclitaxel-loaded lipid-core nanocapsules (PTX-LNC-Bead) intended for oral administration. The PTX-LNC liquid formulation was prepared by interfacial deposition and trapped into calcium alginate beads. These beads were characterized in terms of size, morphology, swelling rate, encapsulation efficiency, and release of PTX and LNC in simulated gastrointestinal fluids. Results showed that the beads were gastro-resistant with low swelling rate and drug release lower than 3.5% at pH 1.2 (2h). At pH 6.8, the beads showed high swelling rate and disintegration after 80 min. Drug release was 60% after 600 min. Particle sizing as a function of time confirmed that LNC were released intact from the beads at pH 6.8 showing that PTX-LNC-Bead is a promising product for PTX oral administration. Our results pave the way for novel formulations intended for drug targeting by the oral route.

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