Novel ultraviolet absorbers derived from cashew nut shell liquid: spectrophotometric, in silico and in vitro assays

Emeli Moura de Araújo; Sheila Garcia; Álvaro Augusto da Costa Leitão; Maria Márcia Murta; Maria Lucília dos Santos; Lúcio Paulo Lima Logrado; Viviane Cândida da Silva; Priscilla Souza Alves; Ana Paula Rodrigues; Luiz Antônio Soares Romeiro; Gisela Maria Dellamora-Ortiz

doi:10.22456/2527-2616.108405

Authors

Emeli Moura de Araújo Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia - Universidade Federal Fluminense
Sheila Garcia Departamento de Fármacos e Medicamentos, Faculdade de Farmácia - Universidade Federal do Rio de Janeiro
Álvaro Augusto da Costa Leitão Instituto de Biofísica Carlos Chagas Filho - Universidade Federal do Rio de Janeiro
Maria Márcia Murta Laboratório de Isolamento e Transformação de Moléculas Orgânicas, Instituto de Química - Universidade de Brasília
Maria Lucília dos Santos Laboratório de Isolamento e Transformação de Moléculas Orgânicas, Instituto de Química - Universidade de Brasília
Lúcio Paulo Lima Logrado Laboratório de Isolamento e Transformação de Moléculas Orgânicas, Instituto de Química - Universidade de Brasília
Viviane Cândida da Silva Laboratório de Isolamento e Transformação de Moléculas Orgânicas, Instituto de Química - Universidade de Brasília
Priscilla Souza Alves Laboratório de Desenvolvimento de Estratégias Terapêuticas - Universidade Católica de Brasília
Ana Paula Rodrigues Laboratório de Desenvolvimento de Estratégias Terapêuticas - Universidade Católica de Brasília
Luiz Antônio Soares Romeiro Faculdade de Ciências da Saúde - Universidade de Brasília; Laboratório de Desenvolvimento de Estratégias Terapêuticas - Universidade Católica de Brasília
Gisela Maria Dellamora-Ortiz Departamento de Fármacos e Medicamentos, Faculdade de Farmácia - Universidade Federal do Rio de Janeiro

DOI:

https://doi.org/10.22456/2527-2616.108405

Keywords:

ultraviolet absorbers, cashew nut, SPF, spectrophotometry

Abstract

The use of sunscreens prevents erythema, photodamage and skin cancer. Natural products have been studied as ultraviolet (UV) absorbers due to their structural similarity to organic UV filters and their lower cost. The cashew nut shell liquid (CNSL) constituents were isolated by our group leading to four mixtures and seventeen pure compounds, which had chromophoric groups similar to organic UV filters. In addition, C15 and C8 CNSL-derivatives molecules were rationally planned as UV absorbers. The aim of this work was to evaluate the potential of CNSL’s constituents and its derivatives as new UV absorbers using spectrophotometric methods, study their physical-chemical properties and toxicity using in silico method, and perform in vitro assays. Mixtures and isolated CNSL compounds were demonstrated to be non-phototoxic when evaluated in a phototoxicity assay using the yeast Saccharomyces cerevisiae. Considering the absorption values on the UV range, 6 compounds showed appropriate SPF values regarding the spectrophotometric test. Additionally, in silico and in vitro evaluations were performed, showing non-oral bioavailability, as well as non-mutagenic, non-genotoxic and non-phototoxic properties for the tested compounds. These results contribute favorably to the aimed use of the compounds under analysis as novel organic UV absorbers that have as precursor the phenolic lipid component of CNSL, a waste product obtained as the by-product of cashew nut food processing.

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Author Biography

Emeli Moura de Araújo, Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia - Universidade Federal Fluminense

Professora do Departamento de Tecnologia Farmacêutica da Faculdade de Farmácia da Universidade Federal Fluminense. Área: Farmacotécnica

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