Pharmaceutical neonatal severity score: proposition of a tool to reduce drug-related problems

Authors

  • Giovanna Webster Negretto Clinical Pharmacy Section, Hospital de Clínicas de Porto Alegre, Porto Alegre - RS, Brazil. https://orcid.org/0000-0003-2081-3781
  • Bruno Simas da Rocha Clinical Pharmacy, Hospital de Clínicas de Porto Alegre, Porto Alegre - RS, Brazil. https://orcid.org/0000-0003-4014-9339
  • Janaína Rodrigues Chagas Gonzatti Medication Management and Logistics Section, Hospital de Clínicas de Porto Alegre, Porto Alegre - RS, Brazil. https://orcid.org/0009-0007-9546-843X
  • Michele Gai Schmidt Clinical Pharmacy, Hospital de Clínicas de Porto Alegre, Porto Alegre - RS, Brazil. https://orcid.org/0009-0008-1205-407X

Keywords:

Neonatology, Pharmacy Service, Medication Review

Abstract

Introduction: The complexity and specific care demands of the neonatal population corroborate the proposition of a tool which optimizes prioritizing activities of the clinical pharmacist. The scarcity of data related to drug monitoring in the Neonatal Intensive Care Unit (NICU) fosters the need for studies and the development of tools in this field.
Objective: To propose a tool in order to help clinical pharmacists reduce drug related problems in NICU.
Methodology: The current study has been carried out in the NICU of a tertiary hospital. It includes all the newborns reviewed by the clinical pharmacist for a period of six months in 2021. A tool was proposed to assess the criticality of newborns, and it was developed taking into account both clinical information and prescribed medications. The score ranks from C1 (most severe health condition) to C7 (less severe health condition). Data have been collected using a pharmaceutical monitoring tool adapted from Martinbiancho et. al, 2021, as well as electronic medical record system.
Results: A total of 316 newborns were admitted in the NICU during the period of the study. From these, a number of 289 were reviewed by the pharmacist - representing 91.5%, as well as 240 were categorized using the severity score. This practice resulted in 126 pharmaceutical interventions (PIs) in medical prescriptions. The rate of intervention/patient classified as C1 score (most severe health condition) was 1.68, followed by 2.18 for C2. The rate obtained for less severe health condition newborns (C7) was 0.24. The analysis in the C1 group resulted in a relative risk (RR) of 2.86 of presenting PIs in the medical prescription (p<0.0001).
Conclusion: The proposed pharmaceutical score proved to be simple and capable of categorizing newborns according to the severity of health conditions. It was also effective in directing follow-up according to the risk of developing Drug Related Problems.

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Published

2025-05-20

How to Cite

1.
Webster Negretto G, Simas da Rocha B, Rodrigues Chagas Gonzatti J, Gai Schmidt M. Pharmaceutical neonatal severity score: proposition of a tool to reduce drug-related problems. Clin Biomed Res [Internet]. 2025 May 20 [cited 2025 Jun. 24];45:e135310. Available from: https://seer.ufrgs.br/index.php/hcpa/article/view/135310

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