Hemophilia throughout the life cycle

Authors

  • Dayenne Helena Catelli Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil. https://orcid.org/0000-0003-3053-9704
  • Ebellins Tabares Calvache Dr https://orcid.org/0000-0003-2368-1622
  • Julia Plentz Portich Hospital de Clínicas de Porto-Alegre, Porto Alegre, Brasil. https://orcid.org/0000-0002-4633-2903
  • Cristiane Seganfredo Weber Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brasil.
  • Daniel Sander Hoffmann Universidade Estadual do Rio Grande do Sul, Guaíba, RS, Brasil. https://orcid.org/0000-0002-9839-3986
  • Guilherme Rasia Bosi Universidade de Caxias do Sul, Porto Alegre, RS, Brasil.
  • Leo Sekine Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
  • Lucia Mariano da Rocha Silla Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.

Keywords:

hemofilia, ciclo de vida, inibidores

Abstract

Hemophilia is an inherited X-linked coagulopathy defined by a deficiency or abnormality in the clotting function of factor VIII (hemophilia A) or factor IX (hemophilia B). The continuous improvement of the treatment has made it possible to monitor the patient through their life cycle with the inherent transition of care, initially by caregivers in childhood and later by the patient himself. Alterations associated with age added to chronic diseases are a constant challenge in the comprehensive treatment of the patient. The inhibitors are IgG alloantibodies directed to exogenous clotting factors, factor VIII or factor IX. The likelihood of developing inhibitors varies from one person with hemophilia to another and depends on the interaction between multiple genetic and environmental factors. This review offers a better understanding of the physiological alterations that allow a comprehensive assessment of the patient with hemophilia.

Downloads

Download data is not yet available.

Downloads

Published

2023-11-29

How to Cite

1.
Catelli DH, Tabares Calvache E, Plentz Portich J, Seganfredo Weber C, Sander Hoffmann D, Rasia Bosi G, Sekine L, Mariano da Rocha Silla L. Hemophilia throughout the life cycle. Clin Biomed Res [Internet]. 2023 Nov. 29 [cited 2025 Jun. 24];43(3). Available from: https://seer.ufrgs.br/index.php/hcpa/article/view/126992

Issue

Vol. 43 No. 3 (2023): Clinical and Biomedical Research

Section

Review Articles

Categories

License

Copyright (c) 2023 Dayenne H. Catelli, Ebellins T. Calvache, Julia P. Portich , Cristiane S. Weber , Daniel S. Hoffmann , Guilherme R. Bosi , Leo Sekine, Lucia MR Silla

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

Most read articles by the same author(s)