Protective effects of heat shock on sepsis and on the systemic inflammatory response syndrome
DOI:
https://doi.org/10.22491/2357-9730.125253Keywords:
Heat shock proteins, sepsis, systemic inflammatory response syndrome, acute respiratory distress syndromeAbstract
Sepsis shock, multiorgan dysfunction and the acute respiratory distress syndrome are major contributors to morbidity and mortality in intensive care units. Animal studies have shown that these forms of injury can be attenuated or prevented if a phenomenon, called the stress response, is activated. The stress response, characterized by a transient downregulation of most cellular products and the upregulation of heat shock
proteins (HSP), has been shown to provide protection to cells and experimental animals if triggered prior to or at an otherwise lethal injury. The mechanisms by which the stress response is protective are not known with certainty, but HSP appear to play an important role. This article summarizes the current literature on the effects of the stress response in protecting cells, organ systems and laboratory animals from lethal forms of systemic
and organic damage.
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