Preliminar analysis of patients with streptococcal tonsillopharyngitis

a comparison of amoxicillin twice a day with amoxicillin three times a day

Authors

  • M. Beatriz Rotta Pereira
  • Manuel R. Pereira
  • Antonio Aguillar
  • Luis Huicho
  • Hugo Trujillo
  • Samir Cahali

DOI:

https://doi.org/10.22491/2357-9730.125221

Keywords:

Streptococcal tonsillopharyngitis, amoxicillin, Streptococus pyogenes

Abstract

OBJECTIVES: To compare the efficacy and tolerance of two posologic amoxicillin schemes in children with tonsillopharyngitis: 45 mg/kg/day in two doses (bid) and 40 mg/kg/day in three doses (tid). MATERIALS AND METHODS: We conducted a multicentric, randomized, single-blinded study, comparing two parallel groups. One hundred and seventy-one ambulatrial patients with ages between 2 and 12 years presenting acute bacterial tonsillopharyngitis were admitted in this study. Patients were evaluated in the selection visit, within three
days of treatment, at the end of treatment and within 28 days after entering the study in order to verify clinical response, possible adverse effects, bacteriological response, and tolerabilty of the medication.
RESULTS: The preliminary analysis of the 171 patients, 86 randomized to “treatment A” group and 85 to “treatment B”, indicates that in the final visit, 83 “treatment A” patients (96.5%) and 82 patients (96.5%) ”treatament B” patients presented clinical criteria of cure.
CONCLUSION: The present data suggest that the therapeutic scheme of amoxicillin administrated twice daily (bd) is as efficient as the three times per day scheme (tid) for the treatament of these patients, with the possible advantage of a greater adherence of patients to the treatment. 

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Published

2022-06-13

How to Cite

1.
Rotta Pereira MB, R. Pereira M, Aguillar A, Huicho L, Trujillo H, Cahali S. Preliminar analysis of patients with streptococcal tonsillopharyngitis: a comparison of amoxicillin twice a day with amoxicillin three times a day. Clin Biomed Res [Internet]. 2022 Jun. 13 [cited 2026 Aug. 9];19(2). Available from: https://seer.ufrgs.br/index.php/hcpa/article/view/125221

Issue

Vol. 19 No. 2 (1999): Revista HCPA

Section

Comunication

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