Bisphosphonates Mechanisms of Action and its Influence in the Endodontic Treatment Prognosis

Abstract

The bisphosphonates are medicines widely used to treat bone mineral loss related diseases due to increasing of bone resorption, being the first choice drugs for osteoporosis treatment and other chronic bone diseases, as Paget disease or osteolytic bone metastasis. These medicines act, direct or indirectly, on osteoclasts and osteoblasts, which results in bone remodeling decreasing, besides presenting inhibitor effects on the inflammatory modulators, what may influence the bone wounds repair process. Within this context, it is proposed to present, by means of a literature review, bisphosphonates mechanisms of action and its influence on the endodontic treatment prognosis, especially with regard to the apical periodontitis repair process. It was concluded bisphosphonates show potential, from their mechanisms of action, potential to influence in the apical periodontitis repair process, and more studies are required to establish a cause-effect relation between bisphosphonates use and the apical periodontitis repair process.