Preliminary study of the biological compatibilityof a zinc oxidecopaibacement. histologicalevaluation of subcutaneous implants in rats.

Authors

  • Carlos Alberto de Souza Costa UNESP
  • Josimeri Hebling UNESP
  • Raphael Carlos Comelli Lia UNESP
  • Heron Fernando de Sousa Gonzaga UNESP
  • Pablo Agustin Vargas UNESP

DOI:

https://doi.org/10.22456/2177-0018.7844

Keywords:

Biocompatible materials, zincoxide, Copaiba balsam

Abstract

Dorsal Implants of polyethylene tubes containing zinc oxide-copaiba(ZO Copaiba)were placed in the subcutaneous connective tissue of 20 rats and histopathological observed on 7, 15, 30 and 60 day periods. In the first period (7days) the material promoted discreet reaction with preponderance of mononuclear cells, contact necrosis and collagen degradation.Through the periods, it was noticed a decreasing the histopathological events and a healing of the open ingregion. In the last periods(30 and 60 days)a connective tissue with dense fibers was covering the tube and surrounding area was showing normal histologic characteristics. Then the ZO Copaibais a poorirritant material when implanted in dorsal skin subcutaneous surgical pockets of rats.

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Author Biographies

Carlos Alberto de Souza Costa, UNESP

Departamento de Patologia – Faculdade de Odontologia – UNESP

Josimeri Hebling, UNESP

Departamento de Clínica Infantil – Faculdade de Odontologia – UNESP

Raphael Carlos Comelli Lia, UNESP

Departamento de Patologia – Faculdade de Odontologia – UNESP

Heron Fernando de Sousa Gonzaga, UNESP

Departamento de Patologia – Faculdade de Odontologia – UNESP

Pablo Agustin Vargas, UNESP

Graduando – Faculdade de Odontologia - UNESP

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Published

1996-04-30

How to Cite

Costa, C. A. de S., Hebling, J., Lia, R. C. C., Gonzaga, H. F. de S., & Vargas, P. A. (1996). Preliminary study of the biological compatibilityof a zinc oxidecopaibacement. histologicalevaluation of subcutaneous implants in rats. Revista Da Faculdade De Odontologia De Porto Alegre, 37(1), 24–26. https://doi.org/10.22456/2177-0018.7844

Issue

Vol. 37 No. 1 (1996)

Section

Original articles

License

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