Micronucleus assay – a biomarker of genotoxic damage in exfoliated oral mucosa cells

Authors

  • Vinicius Coelho CARRARD UFRGS
  • Cynthia Hernandes COSTA FEEVALE
  • Luciana Adolfo FERREIRA
  • Isabel da Silva LAUXEN UFRGS
  • Pantelis Varvaki RADOS UFRGS

DOI:

https://doi.org/10.22456/2177-0018.7512

Keywords:

Micronucleus tests. DNA damage, Chromosome breakage, Cytology, Oral mucosa

Abstract

The aim of this study is to summarise the literature on micronucleus assay, explaining its meaning and its application in exfoliated oral mucosal cells. Micronuclei (MN) is an extra nuclei, originated from chromosome fragments or whole chromosomes that are not included in the main nuclei during mitosis. MNs arise from spontaneous genetic damage or are induced by genotoxic agents. MN analysis has been used as an important tool to biomonitore populations exposed to life-style agents. Studies demonstrate that tobacco and alcohol users, as well as occupationally exposed groups present increased number of MNs in exfoliated oral mucosa cells. Despite the fact that the role of MN frequency has not yet been fully understood, the MNs assay is considered to be an effective biomarker of oral squamous cell carcinoma risk factors effects

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Author Biographies

Vinicius Coelho CARRARD, UFRGS

Doutorando e Mestre em Patologia Bucal - Faculdade de Odontologia/UFRGS

Cynthia Hernandes COSTA, FEEVALE

Estudante de Graduação em Biomedicina - Centro Universitário FEEVALE

Luciana Adolfo FERREIRA

Estudante de Graduação em Ciências Biológicas - Centro Universitário Metodista IPA. Técnica em Patologia Clínica - E.E. Técnica em Saúde do HCPA

Isabel da Silva LAUXEN, UFRGS

Bióloga - Laboratório de Patologia Bucal/Faculdade de Odontologia - UFRGS

Pantelis Varvaki RADOS, UFRGS

Doutor em Patologia - Prof. de Patologia Geral e Buco-dental das Faculdades de Odontologia da UFRGS e da PUCRS

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Published

2007-03-18

How to Cite

CARRARD, V. C., COSTA, C. H., FERREIRA, L. A., LAUXEN, I. da S., & RADOS, P. V. (2007). Micronucleus assay – a biomarker of genotoxic damage in exfoliated oral mucosa cells. Revista Da Faculdade De Odontologia De Porto Alegre, 48(1/3). https://doi.org/10.22456/2177-0018.7512

Issue

v. 48, n. 1/3 (2007)

Section

Original articles

License

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