The study of morphologic changes induced by urethane in an oral chemical carcinogenesis DMBA-induced model

Abstract

The study examined the carcinogenic potential of urethane in lower concent:ration forms according to the experimental oral carcinogenese DMBA-induced model. One hundred Syrian golden hamsters were separated in five experimental groups. Group 1 receivecl 0.5% urethane topical applications along in the lateral border of the tongue; group 2, 6% urethane; group 3, 0.5% urethane + 9,10 dimethyl 1,2-benzantracene (DMBA); group 4, 6% urethane + DMBA; and group 5, assigned positive control, DMBA. The results indicated no histological alterations in groups 1 anel 2 inducecl by 0.5% and 6% urethane. The formation of carcinomas in animals treated with urethane and DMBA wa:s visible in lesser proportions when compareci with the positive control group (DMBA). The 0.5% and 6% urethane decreased carcinogenicity of DMBA and did not present carcinogenic potential for initiation, promotion and/or its progression.