Human leucocyte antigen profile in patients with aids and cytomegalovirus retinitis with and without macular involvement

Autores

  • Nivaldo Vieira de Souza Ribeirão Preto Medical School, University of São Paulo - Department of Ophthalmology, Otorhinolaringology and Head and Neck Surgery
  • Eduardo S.M. Vieira de Souza Federal University of Santa Catarina, Medicine - Division of Surgery
  • Neifi H.S.Deghaide Ribeirão Preto Medical School University Hospital - Laboratory of Molecular Immunology
  • Eduardo Donadi Ribeirão Preto Medical School, University of São Paulo - Department of Internal Medicine, Division of Immunology
  • Maria de Lourdes Veronese Rodrigues Universidade de São Paulo, Ribeirão Preto, Brazil

Palavras-chave:

HLA antigens, AIDS-related opportunistic infections, retinal diseases, Cytomegalovirus retinitis.

Resumo

Introduction: Cytomegalovirus retinitis is one of AIDS ocular manifestations. The objective of the present study was to determine possible associations between class I and II HLA antigens and alleles in patients with AIDS and cytomegalovirus retinitis (CMV-R) with macular involvement.

Method: The study population consisted of 22 patients with AIDS and CMV-R with macular involvement (Group I), 19 patients with AIDS and CMV-R without macular involvement (Group II), and 202 individuals with negative serology for human immunodeficiency virus (Group III - control). Class I HLA antigens were typed by classical serology. Class II alleles were identified using sequence-specific oligonucleotide primers hybridized with amplified DNA. Results: HLA-DRB1*14 and  HLA-DRB1*10 specificities were more frequent among patients with macular involvement, possibly indicating greater susceptibility to this condition. In contrast, the HLA-B35 antigen may be associated with protection against macular involvement since it was significantly more frequent among patients without this involvement.

Conclusions: The HLA-DRB1*14 and HLA-DRB1*10  alleles may favor the development of CMV-R with macular involvement, whereas the HLA-B35 subtype may be associated with protection against macular involvement.

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Biografia do Autor

Maria de Lourdes Veronese Rodrigues, Universidade de São Paulo, Ribeirão Preto, Brazil

Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço

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Publicado

2015-02-25

Como Citar

1.
Vieira de Souza N, S.M. Vieira de Souza E, H.S.Deghaide N, Donadi E, Rodrigues M de LV. Human leucocyte antigen profile in patients with aids and cytomegalovirus retinitis with and without macular involvement. Clin Biomed Res [Internet]. 25º de fevereiro de 2015 [citado 28º de março de 2024];35(1). Disponível em: https://seer.ufrgs.br/index.php/hcpa/article/view/51113