Evaluation of multiple doses of tranexamic acid on blood loss in total knee arthroplasty

Authors

  • Victor Elias Titonelli Instituto Nacional de Traumatologia e Ortopedia. Rio de Janeiro, RJ, Brasil.
  • Douglas Mello Pavão Instituto Nacional de Traumatologia e Ortopedia. Rio de Janeiro, RJ, Brasil.
  • Pedro Purita Paes Leme Instituto Nacional de Traumatologia e Ortopedia. Rio de Janeiro, RJ, Brasil.
  • Renan Teixeira Lobo Instituto Nacional de Traumatologia e Ortopedia. Rio de Janeiro, RJ, Brasil. https://orcid.org/0000-0003-3048-3827
  • Rodrigo Sattamini Pires e Albuquerque Instituto Nacional de Traumatologia e Ortopedia. Rio de Janeiro, RJ, Brasil. Universidade Federal Fluminense. Niterói, RJ, Brasil. https://orcid.org/0000-0001-8209-1548
  • Eduardo Branco de Sousa Instituto Nacional de Traumatologia e Ortopedia. Rio de Janeiro, RJ, Brasil. https://orcid.org/0000-0001-8577-6403

Keywords:

Blood loss, surgical; Arthroplasty, replacement, knee; Osteoarthritis, knee; Tranexamic acid.

Abstract

Objective: To evaluate the efficacy of multiple doses of tranexamic acid (TXA) in blood loss in patients undergoing total knee arthroplasty (TKA).

Methods: Seven patients of both genders over 50 years old undergoingTKA, who received 15 mg/kg intravenous (IV) TXA 30 minutes before the surgical incision and another 3 doses thereafter were included in this report. Blood loss analysis included blood loss at the drain, hemoglobin loss, and estimated blood loss. Statistical analysis was performed.

Results: There was a significant hemoglobin drop after 48 hours, compared to preoperative. Mean blood loss assessed by drain was 20.0 ± 25.17 mL after 24 h. Estimated blood loss was higher after 48 hours compared to 24 hours. No complications were reported in this sample, and no patient received transfusions.

Conclusion: The use of TXA in multiple doses did not prevent the drop in postoperative hemoglobin levels and did not correlate with increased complications.

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Published

2023-11-29

How to Cite

1.
Elias Titonelli V, Mello Pavão D, Purita Paes Leme P, Teixeira Lobo R, Sattamini Pires e Albuquerque R, Branco de Sousa E. Evaluation of multiple doses of tranexamic acid on blood loss in total knee arthroplasty. Clin Biomed Res [Internet]. 2023 Nov. 29 [cited 2025 Jun. 25];43(3). Available from: https://seer.ufrgs.br/index.php/hcpa/article/view/131668

Issue

Vol. 43 No. 3 (2023): Clinical and Biomedical Research

Section

Brief Communication

Categories

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Copyright (c) 2023 Victor Titonelli, Douglas Pavão, Pedro Leme, Renan Lobo , Rodrigo Pires, Eduardo Branco de Sousa

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