Neuroinflammatory Effects of tDCS in Ovariectomized Rats with Chronic Inflammation

Authors

  • Iraci Lucena da Silva Torres Universidade Federal do Rio Grande do Sul
  • Carla Oliveira UFRGS
  • Vanessa Leal Scarabelot UFRGS
  • Rafael Vercelino
  • Andressa Souza UNILASALLE
  • Sonia Fatima da Silva Moreira UFPA
  • Fernanda Visioli UFRGS
  • Wolnei Caumo UFRGS
  • Liciane Fernandes Medeiros UNILASALLE

Keywords:

inflammation, cytokines, estrogen, ovariectomy, tDCS

Abstract

Introduction: Postmenopausal women are more susceptible to chronic condition such as osteoporosis, arthritis and other inflammatory diseases. Then, we investigated the effects of transcranial direct current stimulation (tDCS) upon biomarkers levels in ovariectomized rats subjected to inflammatory model.

Methods: 20 females adult Wistar rats were subjected to ovariectomy and complete Freund’s adjuvant (CFA)-induced inflammation model and divided into two groups: OAS and OAT (active tDCS). Fifteen days after, rats were submitted to bimodal tDCS treatment (20min, 0.5mA, 8 days). Rats were killed 24 h after the last session of tDCS, tissue samples (hypothalamus, cerebral cortex and brainstem) were collected, for biomarkers analysis by ELISA. And paws were extracted for histological analysis.

Results: tDCS increased hypothalamus TNF-α; IL-1β; IL-10 and NGF levels. Also, tDCS group increased cortical cerebral TNF-α and NGF levels; as well as IL-1β levels in the brainstem. Inflammatory profile was observed in the histology of hindpaws, however, no tDCS effect was observed.

Conclusion: bimodal tDCS showed an effect in the inflammatory central axis, with a small effect in the peripheral site evaluated in this current study through the histology.

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Author Biography

Iraci Lucena da Silva Torres, Universidade Federal do Rio Grande do Sul

DEPARTAMENTO DE FARMACOLOGIA

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Published

2021-12-08

How to Cite

1.
Torres IL da S, Oliveira C, Scarabelot VL, Vercelino R, Souza A, Moreira SF da S, Visioli F, Caumo W, Medeiros LF. Neuroinflammatory Effects of tDCS in Ovariectomized Rats with Chronic Inflammation. Clin Biomed Res [Internet]. 2021 Dec. 8 [cited 2025 May 10];41(4). Available from: https://seer.ufrgs.br/index.php/hcpa/article/view/113072

Issue

Vol. 41 No. 4 (2021): Clinical and Biomedical Research

Section

Original Articles

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