Evaluation of multiple doses of tranexamic acid on blood loss in total knee arthroplasty

Autores

  • Victor Titonelli INTO
  • Douglas Pavão INTO
  • Pedro Leme INTO
  • Renan Lobo INTO
  • Rodrigo Pires INTO, UFF
  • Eduardo Branco de Sousa Instituto Nacional de Traumatologia e Ortopedia

Palavras-chave:

Blood loss, surgical; Arthroplasty, replacement, knee; Osteoarthritis, knee; Tranexamic acid.

Resumo

Objective: To evaluate the efficacy of multiple doses of tranexamic acid (TXA) in blood loss in patients undergoing total knee arthroplasty (TKA).

Methods: Seven patients of both genders over 50 years old undergoingTKA, who received 15 mg/kg intravenous (IV) TXA 30 minutes before the surgical incision and another 3 doses thereafter were included in this report. Blood loss analysis included blood loss at the drain, hemoglobin loss, and estimated blood loss. Statistical analysis was performed.

Results: There was a significant hemoglobin drop after 48 hours, compared to preoperative. Mean blood loss assessed by drain was 20.0 ± 25.17 mL after 24 h. Estimated blood loss was higher after 48 hours compared to 24 hours. No complications were reported in this sample, and no patient received transfusions.

Conclusion: The use of TXA in multiple doses did not prevent the drop in postoperative hemoglobin levels and did not correlate with increased complications.

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Publicado

2023-11-29

Como Citar

1.
Elias Titonelli V, Mello Pavão D, Purita Paes Leme P, Teixeira Lobo RTL, Sattamini Pires e Albuquerque R, Branco de Sousa E. Evaluation of multiple doses of tranexamic acid on blood loss in total knee arthroplasty. Clin Biomed Res [Internet]. 29º de novembro de 2023 [citado 29º de fevereiro de 2024];43(3). Disponível em: https://seer.ufrgs.br/index.php/hcpa/article/view/131668

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