Evaluation of multiple doses of tranexamic acid on blood loss in total knee arthroplasty


  • Victor Titonelli INTO
  • Douglas Pavão INTO
  • Pedro Leme INTO
  • Renan Lobo INTO
  • Rodrigo Pires INTO, UFF
  • Eduardo Branco de Sousa Instituto Nacional de Traumatologia e Ortopedia


Blood loss, surgical; Arthroplasty, replacement, knee; Osteoarthritis, knee; Tranexamic acid.


Objective: To evaluate the efficacy of multiple doses of tranexamic acid (TXA) in blood loss in patients undergoing total knee arthroplasty (TKA).

Methods: Seven patients of both genders over 50 years old undergoingTKA, who received 15 mg/kg intravenous (IV) TXA 30 minutes before the surgical incision and another 3 doses thereafter were included in this report. Blood loss analysis included blood loss at the drain, hemoglobin loss, and estimated blood loss. Statistical analysis was performed.

Results: There was a significant hemoglobin drop after 48 hours, compared to preoperative. Mean blood loss assessed by drain was 20.0 ± 25.17 mL after 24 h. Estimated blood loss was higher after 48 hours compared to 24 hours. No complications were reported in this sample, and no patient received transfusions.

Conclusion: The use of TXA in multiple doses did not prevent the drop in postoperative hemoglobin levels and did not correlate with increased complications.


Não há dados estatísticos.




Como Citar

Elias Titonelli V, Mello Pavão D, Purita Paes Leme P, Teixeira Lobo RTL, Sattamini Pires e Albuquerque R, Branco de Sousa E. Evaluation of multiple doses of tranexamic acid on blood loss in total knee arthroplasty. Clin Biomed Res [Internet]. 29º de novembro de 2023 [citado 29º de fevereiro de 2024];43(3). Disponível em: https://seer.ufrgs.br/index.php/hcpa/article/view/131668



Comunicações Breves