P53 protein reactivity in odontogenic lesions: An immunohistochemical study

Authors

  • Márcia Gaiger de OLIVEIRA UFRGS
  • Isabel da Silva LAUXEN UFRGS
  • Manoel Sant'Ana FILHO UFRGS

DOI:

https://doi.org/10.22456/2177-0018.7599

Keywords:

p53, Odontogenic lesions, Immunohistochemistry

Abstract

The purpose of this study was to investigate p53 immunoexpression in some odontogenic lesions. Fifty-seven odontogenic lesions were studied: 12 radicular cysts, 17 dentigerous cysts, 16 calcifying odontogenic cysts and 12 parakeratinized odontogenic keratocyst. All samples were stained for p53. The number of positive cells and staining intensity varied for the different types of lesions. Radicular cysts had the greatest number of positive cells, followed by calcifying odontogenic cysts. Most of the positive cells in the parakeratinized odontogenic keratocysts were in the suprabasal layer. Both parakeratinized odontogenic keratocysts and calcifying odontogenic cysts showed more intense and better defined staining than the other types of cysts. Considering the characteristics of odontogenic keratocysts and the fact that their p53 expression is similar to that of calcifying odontogenic cysts, we suggest that odontogenic lceratocysts should be classified as tumors.

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Author Biographies

Márcia Gaiger de OLIVEIRA, UFRGS

DDS, MsC in Oral Pathology, Federal University of Rio Grande do Sul (UFRGS)

Isabel da Silva LAUXEN, UFRGS

Biologist, Oral Pathology Laboratory, Federal University of Rio Grande do Sul (UFRGS)

Manoel Sant'Ana FILHO, UFRGS

DDS, PhD, Professor of Oral Pathology, Federal University of Rio Grande do Sul (UFRGS)

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Published

2005-09-28

How to Cite

OLIVEIRA, M. G. de, LAUXEN, I. da S., & FILHO, M. S. (2005). P53 protein reactivity in odontogenic lesions: An immunohistochemical study. Revista Da Faculdade De Odontologia De Porto Alegre, 46(2), 31–35. https://doi.org/10.22456/2177-0018.7599

Issue

Vol. 46 No. 2 (2005)

Section

Original articles

License

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