Relationship between salivary proteins and dental caries:
a narrative review of clinical studies
DOI:
https://doi.org/10.22456/2177-0018.137361Palavras-chave:
Boca, Proteoma, Cárie dentária, Enzimas, BiomarcadoresResumo
Aim: to carry out a narrative review of the literature on organic salivary components and their functions, as well as the relationship between these organic components and oral health conditions and dental caries, in an attempt to identify potential candidates for biological markers of dental caries. Literature review: Saliva performs several functions, including buffering, cleansing, maintaining the integrity of hard tissues, and antimicrobial activity. The combined action of these functions contributes to the promotion and maintenance of oral health. The association between salivary proteins and dental caries is presented through a more focused discussion based on systematic reviews and meta-analyses. Discussion: α-Amylase and salivary lipase act to aid the digestion process. The enzymes carbonic anhydrase, urease and ADS act to buffer the oral cavity, PRPs, cystatins, and statherins contribute to the supersaturation of saliva, maintaining the integrity of hard dental tissues. Mucins promote the lubrication of oral surfaces, protecting them against drying out. Peroxidases protect human cells against damage caused by free radicals and reactive oxygen species. Conclusion: Meta-analyses indicate that the concentration of total proteins, the total antioxidant capacity, the activity and concentration of carbonic anhydrase, the activity of urease, and SAD present in saliva may be likely candidates for markers of health and dental caries conditions.
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