Comparison between surgical and conservative methods for the treatment of central granuloma of giant cells described in the literature

Authors

DOI:

https://doi.org/10.22456/2177-0018.122023

Keywords:

Granuloma, giant cell, Diagnosis, Therapeutics

Abstract

Aim: To present, through a literature review, more conservative methods of treatment for Granuloma, establishing comparisons between them, in order to provide the scientific community with more clarity and more effective and safer options for the patient. Literature review: The Central Giant Cell Granuloma (GCCG) is a benign proliferative intraosseous lesion of uncertain etiology and variable clinical behavior that has surgical methods as the most used form of treatment, however, it was observed that surgical methods have a high recurrence rate and a great aesthetic and functional compromise. On the other hand, more conservative methods show complete regression of the lesion and a low recurrence rate, but with the disadvantage of presenting a long period of treatment and some adverse effects. Discussion: There is no protocol for managing GCCG, its clinical management should consider the possibility of combining two or more therapies aiming at better results. Conclusion: Conservative methods are promising for reducing treatment time and preserving aesthetics and function, in addition to having the possibility of being used together according to the patient's need, although no individual treatment is ideal.

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Author Biographies

Victor Arthur Rodrigues de Souza, Universidade Federal de Sergipe

Departamento de Odontologia de Lagarto

Maria Vitória Aragão Freitas, Universidade Federal de Sergipe

Departamento de Odontologia de Lagarto

Maryana Cruz Santos, Universidade Federal de Sergipe

Departamento de Odontologia de Lagarto

Carlos Eduardo Palanch Repeke, Universidade Federal de Sergipe

Departamento de Odontologia de Lagarto

References

Neville BW, Damm DD, Allen CM, Bouquot JE. Patologia oral e maxilofacial. 4. ed. Rio de Janeiro: Elsevier; 2009.

Sinnott BP, Patel M. Giant cell lesion of the jaw as a presenting feature of Noonan syndrome. BMJ Case Rep. 2018;2018:2–5.

Chrcanovic BR, Gomes CC, Gomez RS. Central giant cell lesion of the jaws: an updated analysis of 2270 cases reported in the literature. J Oral Pathol Med. 2018;47(8):731–9.

Zhang Q, He Z, Wang G, Jiang H. Radiotherapy for recurrent central Giant cell granuloma: a case report. Radiation Oncology; 2019;1–4.

Boşca AB, Şovrea AS, Miclăuş V, Ruxanda F, Mihu CM, Melincovici CS, et al. Diagnostic and therapeutic approaches in oral cavity granulomas based on new data concerning their origin and pathogenesis. Rom J Morphol Embryol. 2018;59(3):679–90.

Pham Dang N, Longeac M, Picard M, Devoize L, Barthélémy I. Central giant cell granuloma in children: presentation of different therapeutic options. Rev Stomatol Chir Maxillofac Chir Orale. 2016;117(3):142–6.

Schreuder WH, van den Berg H, Westermann AM, Peacock ZS, de Lange J. Pharmacological and surgical therapy for the central giant cell granuloma: a long-term retrospective cohort study. J Cranio-Maxillofacial Surg. 2017;45(2):232–43.

De Oliveira JP, Olivete F, De Oliveira ND, Giovanini AF, Zielak JC, Klüppel L, et al. Combination therapies for the treatment of recurrent central giant cell lesion in the maxilla: a case report. J Med Case Rep. Journal of Medical Case Reports; 2017;11(1):1–5.

Wang Y, Le A, El Demellawy D, Shago M, Odell M, Johnson-Obaseki S. An aggressive central giant cell granuloma in a pediatric patient: case report and review of literature. J Otolaryngol Head Neck Surg. 2019;48(1):32.

Naot D, Musson DS, Cornish J. The activity of peptides of the calcitonin family in bone. Physiol Rev. 2019;99(1):781–805.

Yavropoulou MP, Yovos JG. Osteoclastogenesis: current knowledge and future perspectives. Journal of Musculoskeletal Neuronal Interactions. 2008 Jul-Sep;8(3):204-16.

Lando L, Silva HM, Cardoso LL, Cruvinel Isaac DL, Teixeira KISS, Avila M. Retinal ischemia following mandible tumor treatment with steroid injection. Arq Bras Oftalmol. 2020;83(6):443–546.

Batista Severo ML, Lopes MLD de S, Miguel MC da C, Germano AR, Nogueira RLM, Turatti E, et al. Immunoexpression of calcitonin and glucocorticoid receptors in central giant cell lesions of the jaws. J Oral Pathol Med. 2018;47(9):907–13.

Upfill-Brown A, Bukata S, Bernthal NM, Felsenfeld AL, Nelson SD, Singh A, et al. Use of denosumab in children with osteoclast bone dysplasias: report of three cases. JBMR Plus. 2019;3(10):1–7.

McArthur D, Palacios E, Nguyen J. Maxillary giant cell granuloma: a long-term follow-up. Ear Nose Throat J. 2019;98(6):E70–2.

Spini R, Juchli M, Fern M, Ram Z. Granuloma gigantocelular de mandíbula en un niño de 6 años de edad. Reporte de un caso. Arch Argent Pediatr. 2019;117(2):173–7.

Dai WY, Tian C, Liu L. Case reports of a giant cell reparative granuloma and a giant cell tumor on temporal bone. Chinese Medical Journal. 2018;131(18):2254–6.

Tecco S, Caruso S, Nota A, Leocata P, Cipollone G, Gatto R, et al. Bilateral central giant cell granuloma of the mandibular angle in three females from the same family. Head Face Med. Head & Face Medicine. 2018;14(1):1–8.

Lipplaa A, Dijkstra S, Gelderblom H. Challenges of denosumab in giant cell tumor of bone, and other giant cell-rich tumors of bone. Curr Opin Oncol. 2019;31(4):329–35.

Published

2022-09-15

How to Cite

Souza, V. A. R. de, Freitas, M. V. A., Santos, M. C., & Repeke, C. E. P. (2022). Comparison between surgical and conservative methods for the treatment of central granuloma of giant cells described in the literature. Revista Da Faculdade De Odontologia De Porto Alegre, 63(1), 129–135. https://doi.org/10.22456/2177-0018.122023

Issue

Section

Review articles