Odontogenic keratocysts: a 22-year epidemiological study and case report

Fernanda Chiguti Yamashita, Gustavo Nascimento de Souza Pinto, Mariliani Chicarelli, Lilian Cristina Vessoni Iwaki, Elen de Souza Tolentino, Liogi Iwaki Filho

Abstract


Odontogenic Keratocyst (OKC) is a cyst that presents local aggression and a high recurrence; thus, a better understanding of its clinical characteristics and treatment options is required. The aim of this study is to report a case and describe the epidemiology and characteristics of OKCs diagnosed at a referral service for patients with oral lesions. Patients with histopathological diagnosis of OKC were included in the sample over 22 years. The study highlights the demographic and clinical-radiological characteristics, as well as the treatment options. In addition, a case of an extensive OKC in the mandible is reported. 3064 medical records were analyzed and 16 cases of OKC (0.52%) were found, with two recurrences (12.5%). The mean age of the patients was 33.19 years, being the third decade of life more affected (31.25%), with equal prevalence for both sexes. The mandible was more affected (68.75%), mainly its body. The differential diagnosis included the dentigerous cyst (11.54%) and the ameloblastoma (11.54%). The most frequent treatment was the curettage enucleation (50%). In the reported case, enucleation associated with cryotherapy was performed, followed by rehabilitation with xenogen graft and osseointegrated implant. OKC presents a wide spectrum of differential diagnoses due to its non-specific clinical-radiographic characteristics. The case reported shows that treatments such as enucleation may be efficient when accompanied by adjuvant techniques.

Keywords


Epidemiology; Diagnosis; Odontogenic cysts

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References


Mosqueda-Taylor A. New findings and controversies in odontogenic tumors. Med Oral Patol Oral Cir Bucal. 2008 1;13(9):E555-8.

Wright JM, Vered M. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Odontogenic and Maxillofacial Bone Tumors. Head Neck Pathol. 2017 Mar;11(1):68-77

Godhi SS, Kukreja P. Keratocystic odontogenic tumor: a review. J Maxillofac Oral Surg. 2009; 8(2): 127–131.

Boffano P, Ruga E, Gallesio C. Keratocystic odontogenic tumor (odontogenic keratocyst): preliminar retrospective review of epidemiologic, clinical, and radiologic features of 261 lesions from University of Turin. J Oral Maxillofac Surg. 2010 Dec;68(12):2994-9.

Sánchez-Burgos R, González-Martín-Moro J, Pérez-Fernández E, Burgueño-García M. Clinical, radiological and therapeutic features of keratocystic odontogenic tumours: a study over a decade. J Clin Exp Dent. 2014;6(3):e259-64.

Abdullah WA. Surgical treatment of keratocystic odontogenic tumour: a review article. Saudi Dent J. 2011 Apr;23(2):61-5.

Da Costa DOP, Maurício AS, De Faria PAS, da-Silva LE, Mosqueda-Taylor A, Lourenço SD. Odontogenic tumors: a retrospective study of four Brazilian diagnostic pathology centers. Med Oral Patol Oral Cir Bucal. 2012 May 1;17(3):e389-94.

Siriwardena BS, Tennakoon TM, Tilakaratne WM. Relative frequency of odontogenic tumors in Sri Lanka: analysis of 1677 cases. Pathol Res Pract. 2012 Apr 15;208(4):225-30.

Johnson NR, Savage NW, Kazoullis S, Batstone MD. A prospective epidemiological study for odontogenic and non-odontogenic lesions of the maxilla and mandible in Queensland. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Apr;115(4):515-22.

Tawfik MA, Zyada MM. Odontogenic tumors in Dakahlia, Egypt: analysis of 82 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Feb;109(2):e67-73.

Osterne RL, Brito RG, Alves AP, Cavalcante RB, Sousa FB. Odontogenic tumors: a 5-year retrospective study in a Brazilian population and analysis of 3406 cases reported in the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Apr;111(4):474-81.

Luppi CR, Bin RB, Nemer MRM, Silva MC, Tolentino ES, Iwaki LCV. Odontogenic tumors: retrospective study of 32 cases diagnosed in a stomatology center in Maringá, Paraná, Brazil. Acta Sci Health Sci. 2018;40:1-5.

Grossmann SM, Machado VC, Xavier GM, Moura MD, Gomez RS, Aguiar MC, et al. Demographic profile of odontogenic and selected nonodontogenic cysts in a Brazilian population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Dec;104(6):e35-41

Kimonis VE, Goldstein AM, Pastakia B, et al. Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome. Am J Med Genet. 1997;69:299–308.

Gupta SR, Jaetli V, Mohanty S, Sharma R, Gupta A. Nevoid basal cell carcinoma syndrome in Indian patients: a clinical and radiological study of 6 cases and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113:99–110.

Ahn SG, Lim YS, Kim DK, Kim SG, Lee SH, Yoon JH. Nevoid basal cell carcinoma syndrome: a retrospective analysis of 33 affected Korean individuals. Int J Oral Maxillofac Surg. 2004;33:458–462.

Mun MJ, Jung DW, Lee CH, Cho KS. Endoscopic removal of a huge keratocystic odontogenic tumor in maxillary sinus. J Craniofac Surg. 2014 Mar;25(2):586-8.

Habibi A, Saghravanian N, Habibi M, Mellati E, Habibi M. Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population. J Oral Sci. 2007 Sep;49(3):229-35.

González-Alva P, Tanaka A, Oku Y, Yoshizawa D, Itoh S, Sakashita H, et al. Keratocystic odontogenic tumor: a retrospective study of 183 cases. J Oral Sci. 2008 Jun;50(2):205-12.

Min JH, Huh KH, Heo MS, Choi SC, Yi WJ, Lee SS, et al. The relationship between radiological features and clinical manifestation and dental expenses of keratocystic odontogenic tumor. Imaging Sci Dent. 2013 Jun;43(2):91-8.

Servato JP, Prieto-Oliveira P, de Faria PR, Loyola AM, Cardoso SV. Odontogenic tumours: 240 cases diagnosed over 31 years at a Brazilian university and a review of international literature. Int J Oral Maxillofac Surg. 2013 Feb;42(2):288-93.

Brannon RB. The odontogenic keratocyst. A clinicopathologic study of 312 cases. Part I. Clinical features. Oral Surg Oral Med Oral Pathol. 1976 Jul;42(1):54-72.

Morgan TA, Burton CC, Qian F. A retrospective review of treatment of the odontogenic keratocyst. J Oral Maxillofac Surg. 2005 May;63(5):635-9.

Myoung H, Hong SP, Hong SD, Lee JI, Lim CY, Choung PH, et al. Odontogenic keratocyst: review of 256 cases for recurrence and clinicopathologic parameters. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Mar;91(3):328-33.

Thompson L, Goldblum J. Head and neck pathology: a volume in the series foundations in diagnostic pathology. Philadelphia (PA): Elsevier; 2006.

Probst FA, Probst M, Pautke Ch, Kaltsi E, Otto S, Schiel S, et al. Magnetic resonance imaging: a useful tool to distinguish between keratocystic odontogenic tumours and odontogenic cysts. Br J Oral Maxillofac Surg. 2015 Mar;53(3):217-22.

Ebenezer V, Ramalingam B. Importance of different modalities of treatment for the management of keratocystic odontogenic tumour with five-year follow-up. Journal of clinical and diagnostic research: J Clin Diagn Res. 2014 Mar;8(3):225-8.

Kshirsagar RA, Bhende RC, Raut PH, Mahajan V, Tapadiya VJ, Singh V. Odontogenic Keratocyst: Developing a Protocol for Surgical Intervention. Ann Maxillofac Surg. 2019;9(1):152–157.

Pogrel MA. The keratocystic odontogenic tumor. Oral Maxillofac Surg Clin North Am. 2013;25:21–30.

Galindo-Moreno P, Hernández-Cortés P, Mesa F, Carranza N, Juodzbalys G, Aguilar M, et al. Slow resorption of anorganic bovine bone by osteoclasts in maxillary sinus augmentation. Clin Implant Dent Relat Res. 2013 Dec;15(6):858-66.

Mordenfeld A, Albrektsson T, Hallman M. A 10-year clinical and radiographic study of implants placed after maxillary sinus floor augmentation with an 80:20 mixture of deproteinized bovine bone and autogenous bone. Clinical implant dentistry and related research, Clin Implant Dent Relat Res. 2014 Jun;16(3):435-46.




DOI: https://doi.org/10.22456/2177-0018.93631

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