Study of the immunohistochemical expression of metalloproteinase – 9 (mmp-9) in periapical lesions

Rachel Pollyana Falcão Lorena, Leorik Pereira da silva, Ana Paula Veras Sobral


Purpose: evaluate the immunohistochemical technique using the expression of metalloproteinase - 9 (MMP-9) in periapical granulomas and cysts root. Methods: We selected 60 cases of periapical lesions of which 31 were periapical granulomas and 29 radicular cysts in 14 years in the Laboratory of Surgical Pathology Professor, Rildege Accioly, Faculty of Dentistry of Pernambuco FOP / UPE. Demographic data were collected through biopsy referral sheets on file in the laboratory. The sample comprised 47 cases were subjected to immunohistochemical technique that was performed using the streptavidin-biotin method, using anti-MMP7. The statistical test used was Fisher's exact test (p ≤ 0.05). Results: 55.3% of the lesions corresponded to periapical granuloma while 44.7% corresponded to cysts. The most prevalent age group was 31-40 years old (40.9%). There was a higher number of cases were white (68.2%) and females (59.6%). Regarding symptoms accounted for 72.1% of asymptomatic lesions and radiographic radiolucent (88.6%), and the jaw anatomic location most affected (59.1%). Regarding the immunohistochemical expression of MMP-9 in periapical lesions, 19 cysts (90.5%) and 25 granulomas (96.2%) were positive showing intensities. Conclusion: The periapical granuloma is inflammatory periapical lesion odontogenic more common in Caucasians aged 31-40 years. The MMP-9 seems to participate in the process of development and maintenance of periapical cysts and granulomas, participating in the initial process of osteolysis primarily degrade various components of the extracellular matrix.


Matrix metalloproteinases; Immunohistochemistry; Odontogenic cysts; Periapical periodontitis


Licença Creative Commons

e-ISSN 2177-0018 / ISSN 0566-1854.

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