The effect of caffeine supplementation on exercise performance evaluated by a novel animal model

Autores

  • Roberto Pacheco da Silva 1Graduate Program in Cardiology and Cardiovascular Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. Interdisciplinary Sleep Research Laboratory, HCPA, Brazil.
  • Denis Martinez Graduate Program in Cardiology and Cardiovascular Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. Graduate Program in Medical Sciences, UFRGS, Porto Alegre, RS, Brazil. Cardiology Unit, Hospital de Clínicas de Porto Alegre (HCPA), UFRGS, Brazil. Interdisciplinary Sleep Research Laboratory, HCPA, Brazil.
  • Cintia Zappe Fiori Graduate Program in Cardiology and Cardiovascular Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. Interdisciplinary Sleep Research Laboratory, HCPA, Brazil.
  • Kelly Silveira da Silva Bueno Graduate Program in Cardiology and Cardiovascular Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. Interdisciplinary Sleep Research Laboratory, HCPA, Brazil.
  • Jhoana Mercedes Uribe Ramos Graduate Program in Medical Sciences, UFRGS, Porto Alegre, RS, Brazil. Interdisciplinary Sleep Research Laboratory, HCPA, Brazil.
  • Renata Schenkel Kaminski
  • Marcia Kraide Fischer
  • Leticia Maria Tedesco Silva
  • Juliana Neves Giordani
  • Juliana Heitich Brendler
  • Juliana Langendorf da Costa Vieira
  • Yasmim de Freitas Dias
  • Laura Martinewski de Oliveira
  • Chaiane Facco Piccin
  • Emerson Ferreira Martins

Palavras-chave:

Exercise, caffeine, energy drinks, running

Resumo

Introduction: Caffeinated drinks are used for improve performance. Animal models represent investigational strategy that circumvents most of the drawbacks of research in humans, including motivational factors and the placebo effect. No animal model that could test whether different forms of administering caffeine affect exercise propensity was found in the literature.

Methods: An animal model of grouped voluntary exercise was tested. Two-month-old male C57/bl mice were housed in a cage fitted with one running wheel and a monitoring system. Six animals per cage were introduced individually. To assess the sensitivity of the model, the effect of different caffeinated drinks was observed in mice exercising ad libitum. During 2 days, the mice received: 1) pure anhydrous caffeine 0.125 mg/mL (PC), 2) cola drink (CC), and 3) caffeine-taurine-glucuronolactone drink (CTG), intercalating wash-out periods of 2 days, receiving pure water.

Results: The distance run during the periods of water ingestion was significantly lower than during the periods of stimulant drinks ingestion: PC (5.6±1.3 km; p = 0.02), of CC ingestion (7.6±0.6 km; p = 0.001), and of CTG ingestion (8.3±1.6 km; p = 0.009). The performances when ingesting the three caffeinated drinks do not follow a dose-response curve.

Conclusions: The model described here was able to measure the effect of caffeine intake on voluntary exercise of mice. The sensitivity of the model to the effect of caffeine needs to be further validated. The action of each component of the drinks on exercise performance needs to be clarified in future research. The present model is adequate for such investigation.

Key words: Exercise; caffeine; energy drinks; running

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Publicado

2017-12-15

Como Citar

1.
da Silva RP, Martinez D, Fiori CZ, Bueno KS da S, Ramos JMU, Kaminski RS, Fischer MK, Silva LMT, Giordani JN, Brendler JH, Vieira JL da C, Dias Y de F, de Oliveira LM, Piccin CF, Martins EF. The effect of caffeine supplementation on exercise performance evaluated by a novel animal model. Clin Biomed Res [Internet]. 15º de dezembro de 2017 [citado 7º de outubro de 2022];37(4). Disponível em: https://seer.ufrgs.br/index.php/hcpa/article/view/74773

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